Different sensitivities of arteries and veins to vasoactive drugs in a hagfish, Eptatretus cirrhatus

Julie M. Foster, Malcolm E. Forster, Kenneth R. Olson

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We used myography on five different arteries and three veins of the hagfish, Eptatretus cirrhatus, to test the response of vessels to vasoactive drugs. Concentration-response curves were generated for carbachol, endothelin-1, arginine vasotocin and the adrenergic agonists, phenylephrine and isoprenaline. pEC50 values indicated that veins were more sensitive to endothelin-1 than were arteries, but the arteries were more sensitive to the cholinergic agonist, carbachol. Segmental arteries did not react to arginine vasotocin, but all other vessels did, and on a molar basis it was the most potent agonist tested. That ventral and dorsal aortas were more sensitive to arginine vasotocin than smaller vessels might indicate that this neurohypophysial peptide has the potential to exert a profound influence on branchial vascular resistance and cardiac output in hagfishes. The results also demonstrate the potential for a variety of endogenous peptides to contribute to central venous tone.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalComparative Biochemistry and Physiology - C Toxicology and Pharmacology
Volume148
Issue number2
DOIs
StatePublished - Aug 2008

    Fingerprint

Keywords

  • Arginine vasotocin
  • Carbachol
  • Cardiovascular
  • Catecholamines
  • Endothelin
  • Hagfish

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Health, Toxicology and Mutagenesis
  • Pharmacology

Cite this