Different sensitivities to ethanol in alcohol-preferring and -nonpreferring rats

Lawrence Lumeng, Marshall B. Waller, William J. McBride, Li Ting-Kai Li

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The sensitivity of the P and NP rats to ethanol was determined by the jumping test [23]. Proper interpretation of this test requires knowledge of the regional differences in the distribution of ethanol as a function of time after ethanol injection. Ethanol concentration in brain was higher than those in tail blood and skeletal muscle within the initial 30 min following the intraperitoneal injection of ethanol and was also higher than that in cerebral blood in the first 15 min. However, after 60 min, ethanol concentrations in brain and tail blood were identical. After ethanol injection (2 g/kg), the P rats jumped 88, 78, 85, 54 and 19% higher than the NP rats at 30, 60, 120, 180 and 240 min, respectively. The tail blood ethanol concentrations did not differ between the P and NP rats after 60 min. The P rats also jumped higher than the NP rats after injection of 1.5 and 2.5 g/kg ethanol. These results indicate that the P rats are innately less sensitive to the effects of ethanol than the NP rats.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume16
Issue number1
DOIs
StatePublished - 1982

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Rats
Ethanol
Alcohols
Blood
Tail
Injections
Brain
Intraperitoneal Injections
Muscle
Skeletal Muscle

Keywords

  • Alcohol preference
  • Distribution of ethanol
  • Ethanol
  • P and NP rats
  • Sensitivity to alcohol

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Different sensitivities to ethanol in alcohol-preferring and -nonpreferring rats. / Lumeng, Lawrence; Waller, Marshall B.; McBride, William J.; Ting-Kai Li, Li.

In: Pharmacology Biochemistry and Behavior, Vol. 16, No. 1, 1982, p. 125-130.

Research output: Contribution to journalArticle

Lumeng, Lawrence ; Waller, Marshall B. ; McBride, William J. ; Ting-Kai Li, Li. / Different sensitivities to ethanol in alcohol-preferring and -nonpreferring rats. In: Pharmacology Biochemistry and Behavior. 1982 ; Vol. 16, No. 1. pp. 125-130.
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