Differential diagnosis of epithelioid and clear cell tumors in the liver

Steven Alexander Mann, Romil Saxena

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A tumor composed of large eosinophilic cells in the liver raises concern for hepatocellular carcinoma, which is typically composed of such cells. However, there are other tumors, both primary and metastatic, that may be composed predominantly of large epithelioid cells. Distinction of these tumors from hepatocellular carcinoma and from each other is of obvious importance for patient management. Similarly, a clear cell tumor anywhere in the body triggers suspicion for renal cell carcinoma. However, other tumors, including hepatocellular carcinoma can rarely be composed entirely of cell cells and the distinction of these from one another, and of primary from metastatic disease is vital. As with the latter, accurate diagnosis is essential for patient management. Using illustrative examples, this article discusses differential diagnosis of liver tumors comprised predominantly of epithelioid cells or clear cells.

Original languageEnglish (US)
JournalSeminars in Diagnostic Pathology
DOIs
StateAccepted/In press - 2017

Fingerprint

Epithelioid Cells
Differential Diagnosis
Liver
Hepatocellular Carcinoma
Neoplasms
Renal Cell Carcinoma

Keywords

  • Angiomyolipoma
  • Clear cell hepatocellular carcinoma
  • Clear cell tumors
  • Epitheliod tumors
  • Epithelioid hemangioendothelioma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Differential diagnosis of epithelioid and clear cell tumors in the liver. / Mann, Steven Alexander; Saxena, Romil.

In: Seminars in Diagnostic Pathology, 2017.

Research output: Contribution to journalArticle

@article{e2de906aacd548d08bc371fb3fcda805,
title = "Differential diagnosis of epithelioid and clear cell tumors in the liver",
abstract = "A tumor composed of large eosinophilic cells in the liver raises concern for hepatocellular carcinoma, which is typically composed of such cells. However, there are other tumors, both primary and metastatic, that may be composed predominantly of large epithelioid cells. Distinction of these tumors from hepatocellular carcinoma and from each other is of obvious importance for patient management. Similarly, a clear cell tumor anywhere in the body triggers suspicion for renal cell carcinoma. However, other tumors, including hepatocellular carcinoma can rarely be composed entirely of cell cells and the distinction of these from one another, and of primary from metastatic disease is vital. As with the latter, accurate diagnosis is essential for patient management. Using illustrative examples, this article discusses differential diagnosis of liver tumors comprised predominantly of epithelioid cells or clear cells.",
keywords = "Angiomyolipoma, Clear cell hepatocellular carcinoma, Clear cell tumors, Epitheliod tumors, Epithelioid hemangioendothelioma",
author = "Mann, {Steven Alexander} and Romil Saxena",
year = "2017",
doi = "10.1053/j.semdp.2016.12.014",
language = "English (US)",
journal = "Seminars in Diagnostic Pathology",
issn = "0740-2570",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Differential diagnosis of epithelioid and clear cell tumors in the liver

AU - Mann, Steven Alexander

AU - Saxena, Romil

PY - 2017

Y1 - 2017

N2 - A tumor composed of large eosinophilic cells in the liver raises concern for hepatocellular carcinoma, which is typically composed of such cells. However, there are other tumors, both primary and metastatic, that may be composed predominantly of large epithelioid cells. Distinction of these tumors from hepatocellular carcinoma and from each other is of obvious importance for patient management. Similarly, a clear cell tumor anywhere in the body triggers suspicion for renal cell carcinoma. However, other tumors, including hepatocellular carcinoma can rarely be composed entirely of cell cells and the distinction of these from one another, and of primary from metastatic disease is vital. As with the latter, accurate diagnosis is essential for patient management. Using illustrative examples, this article discusses differential diagnosis of liver tumors comprised predominantly of epithelioid cells or clear cells.

AB - A tumor composed of large eosinophilic cells in the liver raises concern for hepatocellular carcinoma, which is typically composed of such cells. However, there are other tumors, both primary and metastatic, that may be composed predominantly of large epithelioid cells. Distinction of these tumors from hepatocellular carcinoma and from each other is of obvious importance for patient management. Similarly, a clear cell tumor anywhere in the body triggers suspicion for renal cell carcinoma. However, other tumors, including hepatocellular carcinoma can rarely be composed entirely of cell cells and the distinction of these from one another, and of primary from metastatic disease is vital. As with the latter, accurate diagnosis is essential for patient management. Using illustrative examples, this article discusses differential diagnosis of liver tumors comprised predominantly of epithelioid cells or clear cells.

KW - Angiomyolipoma

KW - Clear cell hepatocellular carcinoma

KW - Clear cell tumors

KW - Epitheliod tumors

KW - Epithelioid hemangioendothelioma

UR - http://www.scopus.com/inward/record.url?scp=85009740739&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009740739&partnerID=8YFLogxK

U2 - 10.1053/j.semdp.2016.12.014

DO - 10.1053/j.semdp.2016.12.014

M3 - Article

JO - Seminars in Diagnostic Pathology

JF - Seminars in Diagnostic Pathology

SN - 0740-2570

ER -