Differential effect of clozapine on weight: A controlled study

Juan R. Bustillo, Robert W. Buchanan, Donna Irish, Alan Breier

Research output: Contribution to journalArticle

161 Scopus citations


Objective: This study examine whether clozapine induces more weight gain than haloperidol and whether weight gain is related to clinical improvement. Method: The weight and symptoms of 39 outpatients with schizophrenia who were randomly assigned to double-blind treatment with either clozapine or haloperidol were assessed. The weight and symptoms of 33 of the patients who chose to take clozapine during a 1-year follow-up after the study ended were also assessed. Results: The patients treated with clozapine gained significantly more weight over baseline (7%) than the haloperidol-treated patients (1%). Weight gain was not significantly correlated with improvements in either positive or negative symptoms. Fifty-eight percent of the patients followed for 1 year gained at least 10% over their baseline weight. Conclusions: Weight gain is an important side effect of clozapine and is unrelated to the drug's differential antipsychotic efficacy.

Original languageEnglish (US)
Pages (from-to)817-819
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number6
StatePublished - Jun 1996
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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