Abstract
Varying doses of d-amphetamine were given i.p. to young (28 day old), adult (approximately 90 day old), and geriatric rats (approximately 2 years old). 30 min after injection, rats were sacrificed and ACH extracted and assayed by pyrolysis gas-liquid chromatography. Total brain acetylcholine (ACh) levels were not significantly different among the control animals in all three groups. d-Amphetamine, however, decreased total levels of ACh in young and geriatric rats without changing levels in adult animals. The changes in young rats were dose-related. These results suggest an important difference in brain cholinergic mechanisms depending upon age.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 145-147 |
| Number of pages | 3 |
| Journal | European Journal of Pharmacology |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1974 |
| Externally published | Yes |
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Keywords
- Acetylcholine
- d-Amphetamine
- Geriatric
- Pyrolysis-gas chromatography
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Differential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric rats. / Vasko, Michael; Domino, Laurence E.; Domino, Edward F.
In: European Journal of Pharmacology, Vol. 27, No. 1, 1974, p. 145-147.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric rats
AU - Vasko, Michael
AU - Domino, Laurence E.
AU - Domino, Edward F.
PY - 1974
Y1 - 1974
N2 - Varying doses of d-amphetamine were given i.p. to young (28 day old), adult (approximately 90 day old), and geriatric rats (approximately 2 years old). 30 min after injection, rats were sacrificed and ACH extracted and assayed by pyrolysis gas-liquid chromatography. Total brain acetylcholine (ACh) levels were not significantly different among the control animals in all three groups. d-Amphetamine, however, decreased total levels of ACh in young and geriatric rats without changing levels in adult animals. The changes in young rats were dose-related. These results suggest an important difference in brain cholinergic mechanisms depending upon age.
AB - Varying doses of d-amphetamine were given i.p. to young (28 day old), adult (approximately 90 day old), and geriatric rats (approximately 2 years old). 30 min after injection, rats were sacrificed and ACH extracted and assayed by pyrolysis gas-liquid chromatography. Total brain acetylcholine (ACh) levels were not significantly different among the control animals in all three groups. d-Amphetamine, however, decreased total levels of ACh in young and geriatric rats without changing levels in adult animals. The changes in young rats were dose-related. These results suggest an important difference in brain cholinergic mechanisms depending upon age.
KW - Acetylcholine
KW - d-Amphetamine
KW - Geriatric
KW - Pyrolysis-gas chromatography
UR - http://www.scopus.com/inward/record.url?scp=0016248150&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016248150&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(74)90212-X
DO - 10.1016/0014-2999(74)90212-X
M3 - Article
C2 - 4851386
AN - SCOPUS:0016248150
VL - 27
SP - 145
EP - 147
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -