Abstract
Varying doses of d-amphetamine were given i.p. to young (28 day old), adult (approximately 90 day old), and geriatric rats (approximately 2 years old). 30 min after injection, rats were sacrificed and ACH extracted and assayed by pyrolysis gas-liquid chromatography. Total brain acetylcholine (ACh) levels were not significantly different among the control animals in all three groups. d-Amphetamine, however, decreased total levels of ACh in young and geriatric rats without changing levels in adult animals. The changes in young rats were dose-related. These results suggest an important difference in brain cholinergic mechanisms depending upon age.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 145-147 |
| Number of pages | 3 |
| Journal | European Journal of Pharmacology |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jun 1974 |
| Externally published | Yes |
Keywords
- Acetylcholine
- Geriatric
- Pyrolysis-gas chromatography
- d-Amphetamine
ASJC Scopus subject areas
- Pharmacology
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Vasko, M. R., Domino, L. E., & Domino, E. F. (1974). Differential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric rats. European Journal of Pharmacology, 27(1), 145-147. https://doi.org/10.1016/0014-2999(74)90212-X