Differential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric rats

Michael R. Vasko, Laurence E. Domino, Edward F. Domino

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Abstract

Varying doses of d-amphetamine were given i.p. to young (28 day old), adult (approximately 90 day old), and geriatric rats (approximately 2 years old). 30 min after injection, rats were sacrificed and ACH extracted and assayed by pyrolysis gas-liquid chromatography. Total brain acetylcholine (ACh) levels were not significantly different among the control animals in all three groups. d-Amphetamine, however, decreased total levels of ACh in young and geriatric rats without changing levels in adult animals. The changes in young rats were dose-related. These results suggest an important difference in brain cholinergic mechanisms depending upon age.

Original languageEnglish (US)
Pages (from-to)145-147
Number of pages3
JournalEuropean Journal of Pharmacology
Volume27
Issue number1
DOIs
StatePublished - Jun 1974

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Keywords

  • Acetylcholine
  • Geriatric
  • Pyrolysis-gas chromatography
  • d-Amphetamine

ASJC Scopus subject areas

  • Pharmacology

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