Differential Effects of Locally Administered Clozapine and Haloperidol on Dopamine Efflux in the Rat Prefrontal Cortex and Caudate‐Putamen

Elizabeth A. Pehek, Bryan Yamamoto

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Abstract: Previous research has shown that systemically administered antipsychotic drugs enhance dopamine release from the nigrostriatal and mesocortical dopamine pathways. However, the degree of enhancement differs as a function of the drug used (atypical versus typical antipsychotic) and the dopamine pathway examined. The present studies examined whether these differences result from differential actions of these drugs on dopamine terminal regions. Clozapine or haloperidol was infused locally into the caudate‐putamen or prefrontal cortex through reverse microdialysis. Although both drugs increased extracellular dopamine levels, clozapine produced greater effects than haloperidol in the prefrontal cortex, whereas haloperidol produced greater effects in the caudate‐putamen. These results suggest that neurochemical differences within dopamine terminal regions may explain the differential actions of antipsychotic drugs on striatal and cortical dopamine release.

Original languageEnglish (US)
Pages (from-to)2118-2124
Number of pages7
JournalJournal of Neurochemistry
Volume63
Issue number6
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Clozapine
Haloperidol
Prefrontal Cortex
Rats
Dopamine
Antipsychotic Agents
Corpus Striatum
Dopamine Agents
Pharmaceutical Preparations
Microdialysis
Research

Keywords

  • Antipsychotics
  • Dopamine D receptors
  • Microdialysis
  • Schizophrenia
  • Serotonin 5‐HT receptors
  • Striatum

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

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N2 - Abstract: Previous research has shown that systemically administered antipsychotic drugs enhance dopamine release from the nigrostriatal and mesocortical dopamine pathways. However, the degree of enhancement differs as a function of the drug used (atypical versus typical antipsychotic) and the dopamine pathway examined. The present studies examined whether these differences result from differential actions of these drugs on dopamine terminal regions. Clozapine or haloperidol was infused locally into the caudate‐putamen or prefrontal cortex through reverse microdialysis. Although both drugs increased extracellular dopamine levels, clozapine produced greater effects than haloperidol in the prefrontal cortex, whereas haloperidol produced greater effects in the caudate‐putamen. These results suggest that neurochemical differences within dopamine terminal regions may explain the differential actions of antipsychotic drugs on striatal and cortical dopamine release.

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