Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells

Shin Yong Park, Dipika Gupta, Chang H. Kim, Roman Dziarski

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Skin protects the body from the environment and is an important component of the innate and adaptive immune systems. Atopic dermatitis and contact dermatitis are among the most frequent inflammatory skin diseases and are both determined by multigenic predisposition, environmental factors, and aberrant immune response. Peptidoglycan Recognition Proteins (Pglyrps) are expressed in the skin and we report here that they modulate sensitivity to experimentally-induced atopic dermatitis and contact dermatitis. Pglyrp3 -/- and Pglyrp4 -/- mice (but not Pglyrp2 -/- mice) develop more severe oxazolone-induced atopic dermatitis than wild type (WT) mice. The common mechanism underlying this increased sensitivity of Pglyrp3 -/- and Pglyrp4 -/- mice to atopic dermatitis is reduced recruitment of Treg cells to the skin and enhanced production and activation Th17 cells in Pglyrp3 -/- and Pglyrp4 -/- mice, which results in more severe inflammation and keratinocyte proliferation. This mechanism is supported by decreased inflammation in Pglyrp3 -/- mice following in vivo induction of Treg cells by vitamin D or after neutralization of IL-17. By contrast, Pglyrp1 -/- mice develop less severe oxazolone-induced atopic dermatitis and also oxazolone-induced contact dermatitis than WT mice. Thus, Pglyrp3 and Pglyrp4 limit over-activation of Th17 cells by promoting accumulation of Treg cells at the site of chronic inflammation, which protects the skin from exaggerated inflammatory response to cell activators and allergens, whereas Pglyrp1 has an opposite pro-inflammatory effect in the skin.

Original languageEnglish
Article numbere24961
JournalPLoS One
Volume6
Issue number9
DOIs
StatePublished - Sep 16 2011

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Dermatitis
contact dermatitis
Th17 Cells
atopic dermatitis
peptidoglycans
Contact Dermatitis
Regulatory T-Lymphocytes
Atopic Dermatitis
Skin
Oxazolone
mice
proteins
inflammation
cells
Inflammation
Chemical activation
Interleukin-17
Immune system
Vitamin D
Allergens

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells. / Park, Shin Yong; Gupta, Dipika; Kim, Chang H.; Dziarski, Roman.

In: PLoS One, Vol. 6, No. 9, e24961, 16.09.2011.

Research output: Contribution to journalArticle

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