Differential expression of IMP3 between male and female mature teratomas-immunohistochemical evidence of malignant nature

Steven Goodman, Liping Zhang, Liang Cheng, Zhong Jiang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aims: Ovarian mature teratoma is a benign tumour, whereas mature teratoma in adult testicular germ cell tumours (TGCTs) is considered to be a malignant tumour. IMP3, an oncofetal protein, plays an important role in embryogenesis and carcinogenesis. IMP3 has been demonstrated to be a malignant biomarker that is mainly expressed in malignant neoplasms rather than benign tissues. The aim of this study was to analyse IMP3 expression in germ cell tumours, and compare its expression between male and female teratomas. Methods and results: One hundred and seventy-eight cases (62 TGCTs, 52 ovarian teratomas, 27 metastatic testicular teratomas, and 37 cases of normal testicular tissue) obtained from the archives of two large academic medical centres were examined for IMP3 expression. Of the 62 TGCTs, 30 had mature teratoma components. IMP3 expression was present in 100% (30/30) of testicular mature teratoma components, and in 96% (26/27) of metastatic testicular teratomas. Other TGCT components also expressed IMP3 in 99% of cases (78/79). IMP3 expression was negative in all female mature teratomas. Conclusions: We describe for the first time an immunostaining marker that has differential expression in male and female mature teratomas, indicating that their pathogenesis differs. High expression of IMP3 in adult mature testicular teratomas supports their malignant nature.

Original languageEnglish
Pages (from-to)483-489
Number of pages7
JournalHistopathology
Volume65
Issue number4
DOIs
StatePublished - Oct 1 2014

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Teratoma
Neoplasms
Germ Cell and Embryonal Neoplasms
Cellular Structures
Embryonic Development
Carcinogenesis
Biomarkers
Testicular Germ Cell Tumor
Testicular Teratoma

Keywords

  • Diagnostic biomarker
  • Germ cell tumour
  • IMP3
  • Teratoma

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Differential expression of IMP3 between male and female mature teratomas-immunohistochemical evidence of malignant nature. / Goodman, Steven; Zhang, Liping; Cheng, Liang; Jiang, Zhong.

In: Histopathology, Vol. 65, No. 4, 01.10.2014, p. 483-489.

Research output: Contribution to journalArticle

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