Differential gene expression in neural stem cells and oligodendrocyte precursor cells: A cDNA microarray analysis

Jian Guo Hu, Sai Li Fu, Kai Hua Zhang, Ying Li, Lan Yin, Pei Hua Lu, Xiao Ming Xu

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The use of neural stem cells (NSCs) or their progeny oligodendrocyte precursor cells (OPCs) represents a promising repair strategy for many neurological disorders. However, the molecular events and biological features during the transition from NSCs to OPCs remain unclear. In the present study, we isolated NSCs from the embryonic rat forebrain and induced them into OPCs by using B104 conditioned medium (B104CM) in vitro. We then employed cDNA array technology to compare changes in gene expression between the two cell populations. Among 1,176 genes examined, 40 were differentially expressed, and some of them may be involved in OPC differentiation from NSCs. Our findings thus provide new insights into the molecular basis of differentiation of OPCs from NSCs.

Original languageEnglish (US)
Pages (from-to)637-646
Number of pages10
JournalJournal of Neuroscience Research
Volume78
Issue number5
DOIs
StatePublished - Dec 1 2004

Keywords

  • Differentiation
  • Gene expression
  • NSCs
  • OPCs
  • cDNA microarray

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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