Primary cilia, an antenna-like structure that protrudes from the apical cell membrane, is essential in endothelial cell (EC) shear responsiveness. Smith et al. show that cilia presentation varies among hiPSC-derived ECs and affects responses to shear, migration, and calcium uptake. Inhibition of HDAC6 restores cilia and mechanosensing of hiPSC-ECs.
- endothelial cells
- human induced pluripotent stem cells
- primary cilia
- shear stress
- tissue engineering
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)