Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells

Quinton Smith, Bria Macklin, Xin Yi Chan, Hannah Jones, Michelle Trempel, Mervin C. Yoder, Sharon Gerecht

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Primary cilia, an antenna-like structure that protrudes from the apical cell membrane, is essential in endothelial cell (EC) shear responsiveness. Smith et al. show that cilia presentation varies among hiPSC-derived ECs and affects responses to shear, migration, and calcium uptake. Inhibition of HDAC6 restores cilia and mechanosensing of hiPSC-ECs.

Original languageEnglish (US)
Pages (from-to)895-908.e6
JournalCell Reports
Volume24
Issue number4
DOIs
StatePublished - Jul 24 2018

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Keywords

  • endothelial cells
  • human induced pluripotent stem cells
  • microfluidics
  • primary cilia
  • shear stress
  • tissue engineering

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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