Differential lateralization of memory discrimination and response bias in temporal lobe epilepsy patients

Guila Glosser, Gayle K. Deutsch, Lynne C. Cole, June Corwin, Andrew J. Saykin

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Recognition memory for words and designs was assessed in epilepsy patients who underwent unilateral anterior temporal lobectomy. Memory was assessed during the intracarotid amobarbital test (IAT) performed prior to surgery and also following surgery. Memory discrimination and response bias lateralized differently. Memory discrimination, or memory accuracy, lateralized as a function of the type of material used in memory testing. Left temporal lobe lesions resulted in more impaired discrimination of verbal materials; right temporal lobe lesions resulted in more impaired discrimination of visuospatial materials. Response bias, the decision rule adopted in situations of uncertainty, was more liberal following left temporal lobe lesions for both verbal and visuospatial materials. Findings suggest that the two cerebral hemispheres are differentially specialized for encoding different types of information in long term memory, and that this impacts on decision strategies in situations of memory uncertainty.

Original languageEnglish (US)
Pages (from-to)502-511
Number of pages10
JournalJournal of the International Neuropsychological Society
Volume4
Issue number5
DOIs
StatePublished - Sep 1 1998
Externally publishedYes

Keywords

  • Intracarotid amobarbital test (IAT)
  • Temporal lobectomy
  • Verbal memory
  • Visuospatial memory

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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