Differentiation, Evaluation, and Application of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells

Yang Lin, Chang Hyun Gil, Mervin Yoder

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

The emergence of induced pluripotent stem cell (iPSC) technology paves the way to generate large numbers of patient-specific endothelial cells (ECs) that can be potentially delivered for regenerative medicine in patients with cardiovascular disease. In the last decade, numerous protocols that differentiate EC from iPSC have been developed by many groups. In this review, we will discuss several common strategies that have been optimized for human iPSC-EC differentiation and subsequent studies that have evaluated the potential of human iPSC-EC as a cell therapy or as a tool in disease modeling. In addition, we will emphasize the importance of using in vivo vessel-forming ability and in vitro clonogenic colony-forming potential as a gold standard with which to evaluate the quality of human iPSC-EC derived from various protocols.

Original languageEnglish (US)
Pages (from-to)2014-2025
Number of pages12
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume37
Issue number11
DOIs
StatePublished - Nov 1 2017

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Induced Pluripotent Stem Cells
Endothelial Cells
Regenerative Medicine
Cell- and Tissue-Based Therapy
Cell Differentiation
Cardiovascular Diseases
Technology

Keywords

  • cardiovascular diseases
  • endothelial cells
  • humans
  • induced pluripotent stem cells
  • regenerative medicine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Differentiation, Evaluation, and Application of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells. / Lin, Yang; Gil, Chang Hyun; Yoder, Mervin.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 37, No. 11, 01.11.2017, p. 2014-2025.

Research output: Contribution to journalReview article

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