Diffusion imaging for tumor grading of supratentorial brain tumors in the first year of life

S. F. Kralik, A. Taha, A. P. Kamer, J. S. Cardinal, T. A. Seltman, Chang Ho

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND PURPOSE: Supratentorial tumors in the first year of life are typically large and heterogeneous at presentation, making differentiation of these CNS neoplasms on pre-operative imaging difficult. We hypothesize that the ADC value can reliably differentiate high- versus low-grade supratentorial tumors in this patient population. MATERIALS AND METHODS: A blinded review of ADC maps was performed on 19 patients with histologically proved supratentorial brain tumors diagnosed within the first year of life. Minimum ADC values obtained by region of interest from 2 neuroradiologists were averaged and compared with World Health Organization tumor grade. ADC values for the entire tumor were also obtained by use of a semi-automated histogram method and compared with World Health Organization tumor grade. Data were analyzed by use of Spearman ρ and Student t test, with a value of P <.05 considered statistically significant. RESULTS: For the manual ADC values, a significant negative correlation was found between the mean minimum ADC and tumor grade (P = .0016). A significant difference was found between the mean minimum ADC of the low-grade (1.14 × 10-3 mm2/s ± 0.30) and high-grade tumors (0.64 × 10-3 mm2/s ± 0.28) (P = .0018). Likewise, the semi-automated method demonstrated a significant negative correlation between the lowest 5th (P = .0002) and 10th (P = .0009) percentile individual tumor ADC values and tumor grade, a significant difference between the mean 5th and 10th percentile ADC values of the low-grade and high-grade groups (P = .0028), and a significant positive correlation with values obtained by manual region-of-interest placement (P <.000001). CONCLUSIONS: ADC maps can differentiate high- versus low-grade neoplasms for supratentorial tumors presenting in the first year of life, given the significant negative correlation between ADC values and tumor grade.

Original languageEnglish (US)
Pages (from-to)815-823
Number of pages9
JournalAmerican Journal of Neuroradiology
Volume35
Issue number4
DOIs
StatePublished - 2014

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Supratentorial Neoplasms
Neoplasm Grading
Brain Neoplasms
Neoplasms

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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Diffusion imaging for tumor grading of supratentorial brain tumors in the first year of life. / Kralik, S. F.; Taha, A.; Kamer, A. P.; Cardinal, J. S.; Seltman, T. A.; Ho, Chang.

In: American Journal of Neuroradiology, Vol. 35, No. 4, 2014, p. 815-823.

Research output: Contribution to journalArticle

Kralik, S. F. ; Taha, A. ; Kamer, A. P. ; Cardinal, J. S. ; Seltman, T. A. ; Ho, Chang. / Diffusion imaging for tumor grading of supratentorial brain tumors in the first year of life. In: American Journal of Neuroradiology. 2014 ; Vol. 35, No. 4. pp. 815-823.
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abstract = "BACKGROUND AND PURPOSE: Supratentorial tumors in the first year of life are typically large and heterogeneous at presentation, making differentiation of these CNS neoplasms on pre-operative imaging difficult. We hypothesize that the ADC value can reliably differentiate high- versus low-grade supratentorial tumors in this patient population. MATERIALS AND METHODS: A blinded review of ADC maps was performed on 19 patients with histologically proved supratentorial brain tumors diagnosed within the first year of life. Minimum ADC values obtained by region of interest from 2 neuroradiologists were averaged and compared with World Health Organization tumor grade. ADC values for the entire tumor were also obtained by use of a semi-automated histogram method and compared with World Health Organization tumor grade. Data were analyzed by use of Spearman ρ and Student t test, with a value of P <.05 considered statistically significant. RESULTS: For the manual ADC values, a significant negative correlation was found between the mean minimum ADC and tumor grade (P = .0016). A significant difference was found between the mean minimum ADC of the low-grade (1.14 × 10-3 mm2/s ± 0.30) and high-grade tumors (0.64 × 10-3 mm2/s ± 0.28) (P = .0018). Likewise, the semi-automated method demonstrated a significant negative correlation between the lowest 5th (P = .0002) and 10th (P = .0009) percentile individual tumor ADC values and tumor grade, a significant difference between the mean 5th and 10th percentile ADC values of the low-grade and high-grade groups (P = .0028), and a significant positive correlation with values obtained by manual region-of-interest placement (P <.000001). CONCLUSIONS: ADC maps can differentiate high- versus low-grade neoplasms for supratentorial tumors presenting in the first year of life, given the significant negative correlation between ADC values and tumor grade.",
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