Diffusion of water in tissues and MRI

C. F. Hazlewood, H. E. Rorschach, C. Lin

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The purpose of this paper is to present an overview of the diffusive behavior of water in biological tissues. The analysis shows that obstructive barriers would have to occupy very large volume fractions in order to account for the reduction in the diffusion coefficient (D) observed in biological systems. Generally, most models lead to the supposition that a substantial fraction (20-40%) of the cell water is hydration water, or that the diffusion coefficient of the cytoplasmic water is reduced substantially from the free water value. Thus, the conclusion that a substantial fraction of cell water has diffusive properties that are altered by the macromolecules of the cytoplasm seems inescapable. The impact of these findings on MRI remain to be determined.

Original languageEnglish (US)
Pages (from-to)214-216
Number of pages3
JournalMagnetic Resonance in Medicine
Volume19
Issue number2
StatePublished - 1991
Externally publishedYes

Fingerprint

Water
Cytoplasm

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Hazlewood, C. F., Rorschach, H. E., & Lin, C. (1991). Diffusion of water in tissues and MRI. Magnetic Resonance in Medicine, 19(2), 214-216.

Diffusion of water in tissues and MRI. / Hazlewood, C. F.; Rorschach, H. E.; Lin, C.

In: Magnetic Resonance in Medicine, Vol. 19, No. 2, 1991, p. 214-216.

Research output: Contribution to journalArticle

Hazlewood, CF, Rorschach, HE & Lin, C 1991, 'Diffusion of water in tissues and MRI', Magnetic Resonance in Medicine, vol. 19, no. 2, pp. 214-216.
Hazlewood CF, Rorschach HE, Lin C. Diffusion of water in tissues and MRI. Magnetic Resonance in Medicine. 1991;19(2):214-216.
Hazlewood, C. F. ; Rorschach, H. E. ; Lin, C. / Diffusion of water in tissues and MRI. In: Magnetic Resonance in Medicine. 1991 ; Vol. 19, No. 2. pp. 214-216.
@article{97a7d923a5144a598a71c5e012b56a6f,
title = "Diffusion of water in tissues and MRI",
abstract = "The purpose of this paper is to present an overview of the diffusive behavior of water in biological tissues. The analysis shows that obstructive barriers would have to occupy very large volume fractions in order to account for the reduction in the diffusion coefficient (D) observed in biological systems. Generally, most models lead to the supposition that a substantial fraction (20-40{\%}) of the cell water is hydration water, or that the diffusion coefficient of the cytoplasmic water is reduced substantially from the free water value. Thus, the conclusion that a substantial fraction of cell water has diffusive properties that are altered by the macromolecules of the cytoplasm seems inescapable. The impact of these findings on MRI remain to be determined.",
author = "Hazlewood, {C. F.} and Rorschach, {H. E.} and C. Lin",
year = "1991",
language = "English (US)",
volume = "19",
pages = "214--216",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Diffusion of water in tissues and MRI

AU - Hazlewood, C. F.

AU - Rorschach, H. E.

AU - Lin, C.

PY - 1991

Y1 - 1991

N2 - The purpose of this paper is to present an overview of the diffusive behavior of water in biological tissues. The analysis shows that obstructive barriers would have to occupy very large volume fractions in order to account for the reduction in the diffusion coefficient (D) observed in biological systems. Generally, most models lead to the supposition that a substantial fraction (20-40%) of the cell water is hydration water, or that the diffusion coefficient of the cytoplasmic water is reduced substantially from the free water value. Thus, the conclusion that a substantial fraction of cell water has diffusive properties that are altered by the macromolecules of the cytoplasm seems inescapable. The impact of these findings on MRI remain to be determined.

AB - The purpose of this paper is to present an overview of the diffusive behavior of water in biological tissues. The analysis shows that obstructive barriers would have to occupy very large volume fractions in order to account for the reduction in the diffusion coefficient (D) observed in biological systems. Generally, most models lead to the supposition that a substantial fraction (20-40%) of the cell water is hydration water, or that the diffusion coefficient of the cytoplasmic water is reduced substantially from the free water value. Thus, the conclusion that a substantial fraction of cell water has diffusive properties that are altered by the macromolecules of the cytoplasm seems inescapable. The impact of these findings on MRI remain to be determined.

UR - http://www.scopus.com/inward/record.url?scp=0025917250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025917250&partnerID=8YFLogxK

M3 - Article

C2 - 1881305

AN - SCOPUS:0025917250

VL - 19

SP - 214

EP - 216

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 2

ER -