Diffusion tensor eigenvector directional color imaging patterns in the evaluation of cerebral white matter tracts altered by tumor

Aaron S. Field, Andrew L. Alexander, Yu-Chien Wu, Khader M. Hasan, Brian Witwer, Behnam Badie

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Purpose: To categorize the varied appearances of tumor-altered white matter (WM) tracts on diffusion tensor eigen-vector directional color maps. Materials and Methods: Diffusion tensor Imaging (DTI) was obtained preoperatively in 13 patients with brain tumors ranging from benign to high-grade malignant, including primary and metastatic lesions, and maps of apparent diffusion coefficient (ADC). fractional anisotropy (FA). and major eigenvector direction were generated. Regions of interest (ROIs) were drawn within identifiable WM tracts affected by tumor, avoiding grossly cystic and necrotic regions, known fiber crossings, and gray matter. Patterns of WM tract alteration were categorized on the basis of qualitative analysis of directional color maps and correlation analysis of ADC and FA. Results: Four basic patterns of WM alteration were identified: 1) normal or nearly normal FA and ADC, with abnormal tract location or tensor directions attributable to bulk mass displacement. 2) moderately decreased FA and increased ADC with normal tract locations and tensor directions, 3) moderately decreased FA and increased ADC with abnormal tensor directions, and 4) near isotropy. FA and ADC were inversely correlated for Patterns 1-3 but did not discriminate edema from infiltrating tumor. However, in the absence of mass displacement, infiltrating tumor was found to produce tensor directional changes that were not observed with vasogenic edema, suggesting the possibility of discrimination on the basis of directional statistics. Conclusion: Tumor alteration of WM tracts tends to produce one of four patterns on FA and directional color maps. Clinical application of these patterns must await further study.

Original languageEnglish (US)
Pages (from-to)555-562
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume20
Issue number4
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

Fingerprint

Anisotropy
Color
Neoplasms
Edema
Diffusion Tensor Imaging
White Matter
Brain Neoplasms
Direction compound

Keywords

  • Cerebral neoplasms
  • Clinical applications
  • Diffusion tensor imaging
  • Directional encoding
  • Preoperative planning

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Diffusion tensor eigenvector directional color imaging patterns in the evaluation of cerebral white matter tracts altered by tumor. / Field, Aaron S.; Alexander, Andrew L.; Wu, Yu-Chien; Hasan, Khader M.; Witwer, Brian; Badie, Behnam.

In: Journal of Magnetic Resonance Imaging, Vol. 20, No. 4, 01.10.2004, p. 555-562.

Research output: Contribution to journalArticle

Field, Aaron S. ; Alexander, Andrew L. ; Wu, Yu-Chien ; Hasan, Khader M. ; Witwer, Brian ; Badie, Behnam. / Diffusion tensor eigenvector directional color imaging patterns in the evaluation of cerebral white matter tracts altered by tumor. In: Journal of Magnetic Resonance Imaging. 2004 ; Vol. 20, No. 4. pp. 555-562.
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