Diffusivity measurements differentiate benign from malignant lesions in patients with peripheral neuropathy or plexopathy

E. L. Yuh, S. Jain Palrecha, G. M. Lagemann, M. Kliot, P. R. Weinstein, Nicholas Barbaro, Cynthia T. Chin

Research output: Contribution to journalArticle

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Abstract

Background and Purpose: Peripheral nerve disorders caused by benign and malignant primary nerve sheath tumors, infiltration or compression of nerves by metastatic disease, and postradiation neuritis demonstrate overlapping features on conventional MR imaging but require vastly different therapeutic approaches. We characterize and compare diffusivities of peripheral nerve lesions in patients undergoing MR neurography for peripheral neuropathy or brachial or lumbosacral plexopathy. Materials and Methods: Twenty-three patients, referred for MR neurography at our institution between 2003 and 2009 for a peripheral mononeuropathy or brachial or lumbosacral plexopathy and whose examinations included DWI, received a definitive diagnosis, based on biopsy results or clinical and imaging follow-up, for a masslike or infiltrative peripheral nerve or plexus lesion suspicious for tumor. Mean ADC values were determined within each lesion and compared across 3 groups (benign lesions, malignant lesions, and postradiation changes). RESULTS: Both ANOVA and Kruskal-Wallis tests demonstrated a statistically significant difference in ADC values across the 3 groups (P = .000023, P=.00056, respectively). Post hoc pair-wise comparisons showed that theADCwithin malignant tumors differed significantly from that within benign tumors and postradiation changes. ADC within benign tumors and postradiation changes did not differ significantly from each other. Conclusions: DWI may be highly effective for the differentiation of benign from malignant peripheral nerve masslike or infiltrative lesions.

Original languageEnglish
Pages (from-to)202-209
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2015

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Peripheral Nervous System Diseases
Peripheral Nerves
Neoplasms
Arm
Nerve Sheath Neoplasms
Mononeuropathies
Neuritis
Analysis of Variance
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

Yuh, E. L., Palrecha, S. J., Lagemann, G. M., Kliot, M., Weinstein, P. R., Barbaro, N., & Chin, C. T. (2015). Diffusivity measurements differentiate benign from malignant lesions in patients with peripheral neuropathy or plexopathy. American Journal of Neuroradiology, 36(1), 202-209. https://doi.org/10.3174/ajnr.A4080

Diffusivity measurements differentiate benign from malignant lesions in patients with peripheral neuropathy or plexopathy. / Yuh, E. L.; Palrecha, S. Jain; Lagemann, G. M.; Kliot, M.; Weinstein, P. R.; Barbaro, Nicholas; Chin, Cynthia T.

In: American Journal of Neuroradiology, Vol. 36, No. 1, 01.01.2015, p. 202-209.

Research output: Contribution to journalArticle

Yuh, E. L. ; Palrecha, S. Jain ; Lagemann, G. M. ; Kliot, M. ; Weinstein, P. R. ; Barbaro, Nicholas ; Chin, Cynthia T. / Diffusivity measurements differentiate benign from malignant lesions in patients with peripheral neuropathy or plexopathy. In: American Journal of Neuroradiology. 2015 ; Vol. 36, No. 1. pp. 202-209.
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