Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging

S. H. Lisanby, W. M. McDonald, E. W. Massey, P. M. Doraiswamy, M. Rozear, Orest Boyko, K. R R Krishnan, C. Nemeroff

Research output: Contribution to journalArticle

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Abstract

Parkinson's disease (PD) is associated with changes in the substantia nigra, which communicates with subcortical nuclei. This study investigates subcortical nuclei volume in PD in vivo by magnetic resonance (MR) imaging. Caudate, putaminal, and thalamic nuclei were measured on axial MR images using a point counting method and systematic sampling. PD patients (n = 21) had significantly smaller subcortical nuclei than age- and sex-matched controls (p < 0.001) and depressed patients (p < 0.01). The decline in PD was not correlated with age, sex, or cortical volume. Depressed patients had significantly smaller caudate and putaminal nuclei than controls (p < 0.05 and 0.01, respectively) but thalamic nuclei were not significantly different. Caudate, putaminal, and thalamic nuclei volumes of controls were significantly negatively correlated with age (r = -0.58, p < 0.01; r = - 0.77, p < 0.001; r = -0.57, p < 0.01, respectively). Depressed subjects demonstrated a negative trend. Volumetric measurements by MR imaging may be a useful in investigating the role of the basal ganglia in neurological disorders.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalJournal of Neural Transmission, Supplement
Issue number40
StatePublished - 1993
Externally publishedYes

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Thalamic Nuclei
Parkinson Disease
Caudate Nucleus
Magnetic Resonance Imaging
Substantia Nigra
Basal Ganglia
Nervous System Diseases
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lisanby, S. H., McDonald, W. M., Massey, E. W., Doraiswamy, P. M., Rozear, M., Boyko, O., ... Nemeroff, C. (1993). Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging. Journal of Neural Transmission, Supplement, (40), 13-21.

Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging. / Lisanby, S. H.; McDonald, W. M.; Massey, E. W.; Doraiswamy, P. M.; Rozear, M.; Boyko, Orest; Krishnan, K. R R; Nemeroff, C.

In: Journal of Neural Transmission, Supplement, No. 40, 1993, p. 13-21.

Research output: Contribution to journalArticle

Lisanby, SH, McDonald, WM, Massey, EW, Doraiswamy, PM, Rozear, M, Boyko, O, Krishnan, KRR & Nemeroff, C 1993, 'Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging', Journal of Neural Transmission, Supplement, no. 40, pp. 13-21.
Lisanby SH, McDonald WM, Massey EW, Doraiswamy PM, Rozear M, Boyko O et al. Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging. Journal of Neural Transmission, Supplement. 1993;(40):13-21.
Lisanby, S. H. ; McDonald, W. M. ; Massey, E. W. ; Doraiswamy, P. M. ; Rozear, M. ; Boyko, Orest ; Krishnan, K. R R ; Nemeroff, C. / Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging. In: Journal of Neural Transmission, Supplement. 1993 ; No. 40. pp. 13-21.
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