Direct Effects of Phosphate on Vascular Cell Function

Wei Ling Lau, Ashwini Pai, Sharon M. Moe, Cecilia M. Giachelli

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

Elevated serum phosphate has clinically been associated with vascular stiffness and cardiovascular mortality. Mechanistic studies over the past decade regarding local effects of phosphate on the vessel wall have provided insight into various pathways that culminate in vascular calcification. Smooth muscle cell phenotype change and apoptosis play prominent roles. The sodium-phosphate cotransporter PiT-1 is required for the osteochondrogenic differentiation of smooth muscle cells in vitro. Less is known about phosphate-driven valve interstitial cell calcification and elastin degradation. In this article, we review the current knowledge about phosphate-induced changes in the vascular wall.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalAdvances in Chronic Kidney Disease
Volume18
Issue number2
DOIs
StatePublished - Mar 1 2011
Externally publishedYes

    Fingerprint

Keywords

  • Chronic kidney disease
  • Elastin degradation
  • Phosphate
  • Smooth muscle cell
  • Vascular calcification

ASJC Scopus subject areas

  • Nephrology

Cite this