Direct measurement of pancreatic enzymes: A comparison of secretagogues

Marian D. Pfefferkorn, Joseph F. Fitzgerald, Joseph M. Croffie, Sandeep K. Gupta, Helena M. Caffrey

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Direct measurement of pancreatic enzymes is the gold standard in the evaluation of exocrine pancreatic function. The purpose of our study was to evaluate the use of cholecystokinin as a single-agent secretagogue for pancreatic drainage studies. Twenty pediatric patients received cholecystokinin (group 1) and 40 patients received either secretin plus placebo (group 2) or secretin plus cholecystokinin (group 3). Duodenal fluid was collected for measurement of lipase, amylase, trypsin, chymotrypsin. The mean lipase and amylase activities were higher in group 3 and the mean trypsin and chymotrypsin activities were higher in group 1, but none of these observations were statistically significant. Group 3 had more patients with all four enzymes being normal (75%) compared to groups 1 (60%) and 2 (50%) (P = 0.262). Patients in all three groups had at least one normal enzyme. Cholecystokinin is useful as a single agent for direct pancreatic enzyme measurements in the absence of commercially available secretin.

Original languageEnglish (US)
Pages (from-to)2211-2216
Number of pages6
JournalDigestive diseases and sciences
Volume47
Issue number10
DOIs
StatePublished - Oct 1 2002

Keywords

  • Exocrine pancreas
  • Lipase
  • Pancreatic enzymes

ASJC Scopus subject areas

  • Gastroenterology

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