Direct measurement of pulmonary microvascular distensibility

S. C. Hillier, P. S. Godbey, C. C. Hanger, J. A. Graham, R. G. Presson, O. Okada, J. H. Linehan, C. A. Dawson, W. W. Wagner

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Pulmonary vascular distensibility has an important influence on pulmonary hemodynamics. Although many measurements of distensibility have been made on large pulmonary vessels, there is less information on microvascular distensibility. We have measured the distensibility of the smallest (<70- μm-diam) precapillary arterioles and postcapillary venules. Isolated dog lobes, at 2.5 cmH2O transpulmonary pressure, were perfused at low flows, which caused the arteriovenous pressure gradient to be very small and thereby permitted accurate estimation of microvascular pressure. As microvascular pressure was systematically varied between 0 and 30 mmHg, subpleural microvascular diameters were determined from computer-enhanced images obtained by videomicroscopy. Arteriolar and venular distensibilities were not different from each other. The microvascular pressure-diameter relationship was alinear with distensibility coefficients of 1-3% mmHg-1, values that are of the same order of magnitude as previously measured distensibilities of 100- to 1,000-μm-diam canine pulmonary vessels.

Original languageEnglish (US)
Pages (from-to)2106-2111
Number of pages6
JournalJournal of Applied Physiology
Volume75
Issue number5
StatePublished - Jan 1 1993

Fingerprint

Pressure
Lung
Video Microscopy
Venules
Arterioles
Blood Vessels
Canidae
Hemodynamics
Dogs

Keywords

  • arterioles
  • dogs
  • pulmonary circulation
  • pulmonary microcirculation
  • pulmonary vascular distensibility
  • venules
  • videomicroscopy

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hillier, S. C., Godbey, P. S., Hanger, C. C., Graham, J. A., Presson, R. G., Okada, O., ... Wagner, W. W. (1993). Direct measurement of pulmonary microvascular distensibility. Journal of Applied Physiology, 75(5), 2106-2111.

Direct measurement of pulmonary microvascular distensibility. / Hillier, S. C.; Godbey, P. S.; Hanger, C. C.; Graham, J. A.; Presson, R. G.; Okada, O.; Linehan, J. H.; Dawson, C. A.; Wagner, W. W.

In: Journal of Applied Physiology, Vol. 75, No. 5, 01.01.1993, p. 2106-2111.

Research output: Contribution to journalArticle

Hillier, SC, Godbey, PS, Hanger, CC, Graham, JA, Presson, RG, Okada, O, Linehan, JH, Dawson, CA & Wagner, WW 1993, 'Direct measurement of pulmonary microvascular distensibility', Journal of Applied Physiology, vol. 75, no. 5, pp. 2106-2111.
Hillier SC, Godbey PS, Hanger CC, Graham JA, Presson RG, Okada O et al. Direct measurement of pulmonary microvascular distensibility. Journal of Applied Physiology. 1993 Jan 1;75(5):2106-2111.
Hillier, S. C. ; Godbey, P. S. ; Hanger, C. C. ; Graham, J. A. ; Presson, R. G. ; Okada, O. ; Linehan, J. H. ; Dawson, C. A. ; Wagner, W. W. / Direct measurement of pulmonary microvascular distensibility. In: Journal of Applied Physiology. 1993 ; Vol. 75, No. 5. pp. 2106-2111.
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