Directional guidance of neuronal migration in the olfactory system by the protein Slit

Wei Wu, Kit Wong, Jin Hui Chen, Zhi Hong Jiang, Sophie Dupuls, Jane Y. Wu, Yi Rao

Research output: Contribution to journalArticle

458 Scopus citations

Abstract

Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Hero we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a direct demonstration of a molecular cue whose concentration gradient guides the direction of migrating neurons. They also support a common guidance mechanism for axon projection and neuronal migration and suggest that Slit may provide a molecular tool with potential therapeutic applications in controlling and directing cell migration.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalNature
Volume400
Issue number6742
DOIs
StatePublished - Jul 22 1999
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Wu, W., Wong, K., Chen, J. H., Jiang, Z. H., Dupuls, S., Wu, J. Y., & Rao, Y. (1999). Directional guidance of neuronal migration in the olfactory system by the protein Slit. Nature, 400(6742), 331-336. https://doi.org/10.1038/22477