Discovery of a novel molecule that regulates tumor growth and metastasis

Chery A. Whipple, Arthur D. Lander, Murray Korc

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell-derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)1250-1253
Number of pages4
JournalTheScientificWorldJournal
Volume8
DOIs
StatePublished - Dec 14 2008

Keywords

  • Angiogenesis
  • GPC1
  • Glypican-1
  • Metastasis
  • Microenvironment
  • PDAC
  • Pancreatic cancer
  • Tumor growth

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

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