Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma

Natalie C. Twine, Jennifer A. Stover, Bonnie Marshall, Gary Dukart, Manuel Hidalgo, Walter Stadler, Theodore Logan, Janice Dutcher, Gary Hudes, Andrew J. Dorner, Donna K. Slonim, William L. Trepicchio, Michael E. Burczynski

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109 Scopus citations

Abstract

Expression profiling has demonstrated that transcriptomes of primary malignancies differ from those in normal tissue. It is unknown, however, whether there exist "surrogate" transcriptional markers in peripheral blood mononuclear cells (PBMCs) of patients with solid tumors. We identified transcripts expressed differentially between PBMCs from renal cell carcinoma patients and normal subjects, some of which appear to reflect specific immune responses of circulating cells. We also identified small sets of predictor genes distinguishing PBMCs from renal cell carcinoma patients and normal volunteers with high accuracy. The present findings have important implications for diagnosis and future clinical pharmacogenomic studies of antitumor therapies.

Original languageEnglish (US)
Pages (from-to)6069-6075
Number of pages7
JournalCancer Research
Volume63
Issue number18
StatePublished - Sep 15 2003

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Twine, N. C., Stover, J. A., Marshall, B., Dukart, G., Hidalgo, M., Stadler, W., Logan, T., Dutcher, J., Hudes, G., Dorner, A. J., Slonim, D. K., Trepicchio, W. L., & Burczynski, M. E. (2003). Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma. Cancer Research, 63(18), 6069-6075.