Disease modeling and cell based therapy with iPSC

Future therapeutic option with fast and safe application

Changsung Kim

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Induced pluripotent stem cell (iPSC) technology has shown us great hope to treat various human diseases which have been known as untreatable and further endows personalized medicine for future therapy without ethical issues and immunological rejection which embryonic stem cell (hES) treatment has faced. It has been agreed that iPSCs knowledge can be harnessed from disease modeling which mimics human pathological development rather than trials utilizing conventional rodent and cell lines. Now, we can routinely generate iPSC from patient specific cell sources, such as skin fibroblast, hair follicle cells, patient blood samples and even urine containing small amount of epithelial cells. iPSC has both similarity and dissimilarity to hES. iPSC is similar enough to regenerate tissue and even full organism be generated. This makes iPSC even better choice to perform disease modeling as well as cell based therapy. Tissue memory containing iPSC from mature leukocytes would be beneficial for curing cancer and infectious disease. In this review, the benefit of iPSC for translational approaches will be presented.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalBlood Research
Volume49
Issue number1
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Induced Pluripotent Stem Cells
Cell- and Tissue-Based Therapy
Therapeutics
Hope
Precision Medicine
Hair Follicle
Human Development
Embryonic Stem Cells
Ethics
Communicable Diseases
Rodentia
Blood Cells
Leukocytes
Fibroblasts
Epithelial Cells
Urine
Technology
Cell Line
Skin

Keywords

  • Blood disorder
  • Cell transplant
  • IPSC
  • Patient specific medicine
  • Stem cell

ASJC Scopus subject areas

  • Hematology

Cite this

Disease modeling and cell based therapy with iPSC : Future therapeutic option with fast and safe application. / Kim, Changsung.

In: Blood Research, Vol. 49, No. 1, 2014, p. 7-14.

Research output: Contribution to journalReview article

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