Disease processes in epithelia: the role of the actin cytoskeleton and altered surface membrane polarity

Jeffrey Leiser, Bruce A. Molitoris

Research output: Contribution to journalReview article

39 Scopus citations


The establisment and maintenance of cell polarity is essential for normal epithelial function. Disruption of the underlying processes, either as a primary inborn defect or as a secondary result of other pathologic processes, can lead to loss of epithelial polarity and further cellular and organ-level dysfunction. Continued elucidation of the processes involved may prove fruitful both in the understanding of basic cell biology and in the understanding and treatment of a variety of disease states.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalBBA - Molecular Basis of Disease
Issue number1
StatePublished - Nov 25 1993



  • Cytoskeleton
  • Epithelial polarity
  • Ischemia
  • Microvillous inclusion disease
  • Polycystic kidney disease
  • Proximal tubule

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology
  • Molecular Medicine

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