DisProt 7.0: A major update of the database of disordered proteins

Damiano Piovesan, Francesco Tabaro, Ivan Mičetić, Marco Necci, Federica Quaglia, Christopher J. Oldfield, Maria Cristina Aspromonte, Norman E. Davey, Radoslav Davidović, Zsuzsanna Dosztányi, Arne Elofsson, Alessandra Gasparini, András Hatos, Andrey V. Kajava, Lajos Kalmar, Emanuela Leonardi, Tamas Lazar, Sandra Macedo-Ribeiro, Mauricio Macossay-Castillo, Attila MeszarosGiovanni Minervini, Nikoletta Murvai, Jordi Pujols, Daniel B. Roche, Edoardo Salladini, Eva Schad, Antoine Schramm, Beata Szabo, Agnes Tantos, Fiorella Tonello, Konstantinos D. Tsirigos, Nevena Veljković, Salvador Ventura, Wim Vranken, Per Warholm, Vladimir N. Uversky, A. Dunker, Sonia Longhi, Peter Tompa, Silvio C.E. Tosatto

Research output: Contribution to journalArticle

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Abstract

The Database of Protein Disorder (DisProt, URL: www.disprot.org) has been significantly updated and upgraded since its last major renewal in 2007. The current release holds information on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions that exist and function without a well-defined three-dimensional structure. We have re-curated previous entries to purge DisProt from conflicting cases, and also upgraded the functional classification scheme to reflect continuous advance in the field in the past 10 years or so. We define IDPs as proteins that are disordered along their entire sequence, i.e. entirely lack structural elements, and IDRs as regions that are at least five consecutive residues without well-defined structure. We base our assessment of disorder strictly on experimental evidence, such as X-ray crystallography and nuclear magnetic resonance (primary techniques) and a broad range of other experimental approaches (secondary techniques). Confident and ambiguous annotations are highlighted separately. DisProt 7.0 presents classified knowledge regarding the experimental characterization and functional annotations of IDPs/IDRs, and is intended to provide an invaluable resource for the research community for a better understanding structural disorder and for developing better computational tools for studying disordered proteins.

Original languageEnglish (US)
Pages (from-to)D219-D227
JournalNucleic Acids Research
Volume45
Issue numberD1
DOIs
StatePublished - Jan 1 2017

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Inosine Diphosphate
Protein Databases
Intrinsically Disordered Proteins
X Ray Crystallography
Proteins
Magnetic Resonance Spectroscopy
Research

ASJC Scopus subject areas

  • Genetics

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Piovesan, D., Tabaro, F., Mičetić, I., Necci, M., Quaglia, F., Oldfield, C. J., ... Tosatto, S. C. E. (2017). DisProt 7.0: A major update of the database of disordered proteins. Nucleic Acids Research, 45(D1), D219-D227. https://doi.org/10.1093/nar/gkw1056

DisProt 7.0 : A major update of the database of disordered proteins. / Piovesan, Damiano; Tabaro, Francesco; Mičetić, Ivan; Necci, Marco; Quaglia, Federica; Oldfield, Christopher J.; Aspromonte, Maria Cristina; Davey, Norman E.; Davidović, Radoslav; Dosztányi, Zsuzsanna; Elofsson, Arne; Gasparini, Alessandra; Hatos, András; Kajava, Andrey V.; Kalmar, Lajos; Leonardi, Emanuela; Lazar, Tamas; Macedo-Ribeiro, Sandra; Macossay-Castillo, Mauricio; Meszaros, Attila; Minervini, Giovanni; Murvai, Nikoletta; Pujols, Jordi; Roche, Daniel B.; Salladini, Edoardo; Schad, Eva; Schramm, Antoine; Szabo, Beata; Tantos, Agnes; Tonello, Fiorella; Tsirigos, Konstantinos D.; Veljković, Nevena; Ventura, Salvador; Vranken, Wim; Warholm, Per; Uversky, Vladimir N.; Dunker, A.; Longhi, Sonia; Tompa, Peter; Tosatto, Silvio C.E.

In: Nucleic Acids Research, Vol. 45, No. D1, 01.01.2017, p. D219-D227.

Research output: Contribution to journalArticle

Piovesan, D, Tabaro, F, Mičetić, I, Necci, M, Quaglia, F, Oldfield, CJ, Aspromonte, MC, Davey, NE, Davidović, R, Dosztányi, Z, Elofsson, A, Gasparini, A, Hatos, A, Kajava, AV, Kalmar, L, Leonardi, E, Lazar, T, Macedo-Ribeiro, S, Macossay-Castillo, M, Meszaros, A, Minervini, G, Murvai, N, Pujols, J, Roche, DB, Salladini, E, Schad, E, Schramm, A, Szabo, B, Tantos, A, Tonello, F, Tsirigos, KD, Veljković, N, Ventura, S, Vranken, W, Warholm, P, Uversky, VN, Dunker, A, Longhi, S, Tompa, P & Tosatto, SCE 2017, 'DisProt 7.0: A major update of the database of disordered proteins', Nucleic Acids Research, vol. 45, no. D1, pp. D219-D227. https://doi.org/10.1093/nar/gkw1056
Piovesan D, Tabaro F, Mičetić I, Necci M, Quaglia F, Oldfield CJ et al. DisProt 7.0: A major update of the database of disordered proteins. Nucleic Acids Research. 2017 Jan 1;45(D1):D219-D227. https://doi.org/10.1093/nar/gkw1056
Piovesan, Damiano ; Tabaro, Francesco ; Mičetić, Ivan ; Necci, Marco ; Quaglia, Federica ; Oldfield, Christopher J. ; Aspromonte, Maria Cristina ; Davey, Norman E. ; Davidović, Radoslav ; Dosztányi, Zsuzsanna ; Elofsson, Arne ; Gasparini, Alessandra ; Hatos, András ; Kajava, Andrey V. ; Kalmar, Lajos ; Leonardi, Emanuela ; Lazar, Tamas ; Macedo-Ribeiro, Sandra ; Macossay-Castillo, Mauricio ; Meszaros, Attila ; Minervini, Giovanni ; Murvai, Nikoletta ; Pujols, Jordi ; Roche, Daniel B. ; Salladini, Edoardo ; Schad, Eva ; Schramm, Antoine ; Szabo, Beata ; Tantos, Agnes ; Tonello, Fiorella ; Tsirigos, Konstantinos D. ; Veljković, Nevena ; Ventura, Salvador ; Vranken, Wim ; Warholm, Per ; Uversky, Vladimir N. ; Dunker, A. ; Longhi, Sonia ; Tompa, Peter ; Tosatto, Silvio C.E. / DisProt 7.0 : A major update of the database of disordered proteins. In: Nucleic Acids Research. 2017 ; Vol. 45, No. D1. pp. D219-D227.
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