Disrupted modular architecture of cerebellum in schizophrenia: A graph theoretic analysis

Dae Jin Kim, Jerillyn S. Kent, Amanda R. Bolbecker, Olaf Sporns, Hu Cheng, Sharlene D. Newman, Aina Puce, Brian O'Donnell, William P. Hetrick

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Recent studies of schizophrenia have revealed cognitive and memory deficits that are accompanied by disruptions of neuronal connectivity in cortical and subcortical brain regions. More recently, alterations of topological organization of structural networks in schizophrenia are also being identified using graph theoretical analysis. However, the role of the cerebellum in this network structure remains largely unknown. In this study, global network measures obtained from diffusion tensor imaging were computed in the cerebella of 25 patients with schizophrenia and 36 healthy volunteers. While cerebellar global network characteristics were slightly altered in schizophrenia patients compared with healthy controls, the patients showed a retained small-world network organization. The modular architecture, however, was changed mainly in crus II. Furthermore, schizophrenia patients had reduced correlations between modularity and microstructural integrity, as measured by fractional anisotropy (FA) in lobules I-IV and X. Finally, FA alterations were significantly correlated with the Positive and Negative Syndrome Scale symptom scores in schizophrenia patients. Taken together, our data suggest that schizophrenia patients have altered network architecture in the cerebellum with reduced local microstructural connectivity and that cerebellar structural abnormalities are associated symptoms of the disorder.

Original languageEnglish (US)
Pages (from-to)1216-1226
Number of pages11
JournalSchizophrenia Bulletin
Volume40
Issue number6
DOIs
StatePublished - Nov 1 2014

Fingerprint

Cerebellum
Schizophrenia
Anisotropy
Diffusion Tensor Imaging
Memory Disorders
Healthy Volunteers
Brain

Keywords

  • Cerebellum
  • Diffusion tensor imaging
  • Modular architecture
  • Schizophrenia
  • Structural connectivity
  • Structural network

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Kim, D. J., Kent, J. S., Bolbecker, A. R., Sporns, O., Cheng, H., Newman, S. D., ... Hetrick, W. P. (2014). Disrupted modular architecture of cerebellum in schizophrenia: A graph theoretic analysis. Schizophrenia Bulletin, 40(6), 1216-1226. https://doi.org/10.1093/schbul/sbu059

Disrupted modular architecture of cerebellum in schizophrenia : A graph theoretic analysis. / Kim, Dae Jin; Kent, Jerillyn S.; Bolbecker, Amanda R.; Sporns, Olaf; Cheng, Hu; Newman, Sharlene D.; Puce, Aina; O'Donnell, Brian; Hetrick, William P.

In: Schizophrenia Bulletin, Vol. 40, No. 6, 01.11.2014, p. 1216-1226.

Research output: Contribution to journalArticle

Kim, DJ, Kent, JS, Bolbecker, AR, Sporns, O, Cheng, H, Newman, SD, Puce, A, O'Donnell, B & Hetrick, WP 2014, 'Disrupted modular architecture of cerebellum in schizophrenia: A graph theoretic analysis', Schizophrenia Bulletin, vol. 40, no. 6, pp. 1216-1226. https://doi.org/10.1093/schbul/sbu059
Kim DJ, Kent JS, Bolbecker AR, Sporns O, Cheng H, Newman SD et al. Disrupted modular architecture of cerebellum in schizophrenia: A graph theoretic analysis. Schizophrenia Bulletin. 2014 Nov 1;40(6):1216-1226. https://doi.org/10.1093/schbul/sbu059
Kim, Dae Jin ; Kent, Jerillyn S. ; Bolbecker, Amanda R. ; Sporns, Olaf ; Cheng, Hu ; Newman, Sharlene D. ; Puce, Aina ; O'Donnell, Brian ; Hetrick, William P. / Disrupted modular architecture of cerebellum in schizophrenia : A graph theoretic analysis. In: Schizophrenia Bulletin. 2014 ; Vol. 40, No. 6. pp. 1216-1226.
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