Ganem et al. report that the C. elegans enzymatic-inactive ADR-1 regulates A-to-I RNA editing by directing editing by ADR-2, mainly at the L4 developmental stage. Changes in RNA editing levels severely affect normal development by changing RNA levels, but not protein levels.
- C. elegans
- gene expression
- organism development
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)