Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing

Nabeel S. Ganem, Noa Ben-Asher, Aidan C. Manning, Sarah N. Deffit, Michael C. Washburn, Emily C. Wheeler, Gene W. Yeo, Orna Ben Naim Zgayer, Einav Mantsur, Heather Hundley, Ayelet T. Lamm

Research output: Contribution to journalArticle

Abstract

Ganem et al. report that the C. elegans enzymatic-inactive ADR-1 regulates A-to-I RNA editing by directing editing by ADR-2, mainly at the L4 developmental stage. Changes in RNA editing levels severely affect normal development by changing RNA levels, but not protein levels.

Original languageEnglish (US)
Pages (from-to)1244-1253.e4
JournalCell Reports
Volume27
Issue number4
DOIs
StatePublished - Apr 23 2019

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RNA Editing
RNA
Proteins
immune RNA

Keywords

  • ADAR
  • C. elegans
  • gene expression
  • organism development
  • transcriptomics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ganem, N. S., Ben-Asher, N., Manning, A. C., Deffit, S. N., Washburn, M. C., Wheeler, E. C., ... Lamm, A. T. (2019). Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing. Cell Reports, 27(4), 1244-1253.e4. https://doi.org/10.1016/j.celrep.2019.03.095

Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing. / Ganem, Nabeel S.; Ben-Asher, Noa; Manning, Aidan C.; Deffit, Sarah N.; Washburn, Michael C.; Wheeler, Emily C.; Yeo, Gene W.; Zgayer, Orna Ben Naim; Mantsur, Einav; Hundley, Heather; Lamm, Ayelet T.

In: Cell Reports, Vol. 27, No. 4, 23.04.2019, p. 1244-1253.e4.

Research output: Contribution to journalArticle

Ganem, NS, Ben-Asher, N, Manning, AC, Deffit, SN, Washburn, MC, Wheeler, EC, Yeo, GW, Zgayer, OBN, Mantsur, E, Hundley, H & Lamm, AT 2019, 'Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing', Cell Reports, vol. 27, no. 4, pp. 1244-1253.e4. https://doi.org/10.1016/j.celrep.2019.03.095
Ganem NS, Ben-Asher N, Manning AC, Deffit SN, Washburn MC, Wheeler EC et al. Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing. Cell Reports. 2019 Apr 23;27(4):1244-1253.e4. https://doi.org/10.1016/j.celrep.2019.03.095
Ganem, Nabeel S. ; Ben-Asher, Noa ; Manning, Aidan C. ; Deffit, Sarah N. ; Washburn, Michael C. ; Wheeler, Emily C. ; Yeo, Gene W. ; Zgayer, Orna Ben Naim ; Mantsur, Einav ; Hundley, Heather ; Lamm, Ayelet T. / Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing. In: Cell Reports. 2019 ; Vol. 27, No. 4. pp. 1244-1253.e4.
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