Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing

Nabeel S. Ganem, Noa Ben-Asher, Aidan C. Manning, Sarah N. Deffit, Michael C. Washburn, Emily C. Wheeler, Gene W. Yeo, Orna Ben Naim Zgayer, Einav Mantsur, Heather A. Hundley, Ayelet T. Lamm

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Abstract

Ganem et al. report that the C. elegans enzymatic-inactive ADR-1 regulates A-to-I RNA editing by directing editing by ADR-2, mainly at the L4 developmental stage. Changes in RNA editing levels severely affect normal development by changing RNA levels, but not protein levels.

Original languageEnglish (US)
Pages (from-to)1244-1253.e4
JournalCell Reports
Volume27
Issue number4
DOIs
StatePublished - Apr 23 2019

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Keywords

  • ADAR
  • C. elegans
  • gene expression
  • organism development
  • transcriptomics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ganem, N. S., Ben-Asher, N., Manning, A. C., Deffit, S. N., Washburn, M. C., Wheeler, E. C., Yeo, G. W., Zgayer, O. B. N., Mantsur, E., Hundley, H. A., & Lamm, A. T. (2019). Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing. Cell Reports, 27(4), 1244-1253.e4. https://doi.org/10.1016/j.celrep.2019.03.095