Disruption of gene co-expression network along the progression of Alzheimer's disease

Yurika Upadhyaya, Linhui Xie, Paul Salama, Kwangsik Nho, Andrew J. Saykin, Jingwen Yan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Alzheimer's disease (AD) is one of the most common brain dementia characterized by gradual deterioration of cognitive function. While it has been affecting an increasing number of aging population and become a nation-wide public health crisis, the underlying mechanism remains largely unknown. To address this problem, we propose to investigate the gene co-expression network changes along AD progression. Unlike extant work that focus on cognitive normals (CNs) and AD patients, we aim to capture the network changes during the full range of disease progression, from CN, early mild cognitive impairment (EMCI) to late MCI (LMCI) and AD. In addition, many existing differential co-expression network analyses estimate the network of each group independently, which may possibly lead to suboptimal results. Assuming that the gene co-expression patterns should be largely similar in consecutive disease stages, we propose to apply a modified joint graphical lasso model to estimate the networks of multiple diagnostic groups simultaneously. The permutation results shows that JGL model is much less likely to generate false positives with the similarity constraint. By comparing the estimated gene co-expression networks of all disease stages, we identified 8 clusters showing gradual changes during the progression of AD.

Original languageEnglish (US)
Title of host publication2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728108483
DOIs
StatePublished - May 2019
Event2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Chicago, United States
Duration: May 19 2019May 22 2019

Publication series

Name2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings

Conference

Conference2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019
CountryUnited States
CityChicago
Period5/19/195/22/19

Fingerprint

Alzheimer Disease
Genes
Gene Expression
Disease Progression
Cognition
Dementia
Public Health
Joints
Alzheimer's disease
Disruption
Gene
Progression
Public health
Deterioration
Brain
Aging of materials
Population

Keywords

  • Alzheimer's disease
  • Differential co-expression
  • Early detection

ASJC Scopus subject areas

  • Artificial Intelligence
  • Signal Processing
  • Information Systems and Management
  • Biomedical Engineering
  • Health Informatics
  • Radiology Nuclear Medicine and imaging

Cite this

Upadhyaya, Y., Xie, L., Salama, P., Nho, K., Saykin, A. J., & Yan, J. (2019). Disruption of gene co-expression network along the progression of Alzheimer's disease. In 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings [8834551] (2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BHI.2019.8834551

Disruption of gene co-expression network along the progression of Alzheimer's disease. / Upadhyaya, Yurika; Xie, Linhui; Salama, Paul; Nho, Kwangsik; Saykin, Andrew J.; Yan, Jingwen.

2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2019. 8834551 (2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Upadhyaya, Y, Xie, L, Salama, P, Nho, K, Saykin, AJ & Yan, J 2019, Disruption of gene co-expression network along the progression of Alzheimer's disease. in 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings., 8834551, 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings, Institute of Electrical and Electronics Engineers Inc., 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019, Chicago, United States, 5/19/19. https://doi.org/10.1109/BHI.2019.8834551
Upadhyaya Y, Xie L, Salama P, Nho K, Saykin AJ, Yan J. Disruption of gene co-expression network along the progression of Alzheimer's disease. In 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2019. 8834551. (2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings). https://doi.org/10.1109/BHI.2019.8834551
Upadhyaya, Yurika ; Xie, Linhui ; Salama, Paul ; Nho, Kwangsik ; Saykin, Andrew J. ; Yan, Jingwen. / Disruption of gene co-expression network along the progression of Alzheimer's disease. 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2019. (2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings).
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