Dissecting the molecular landscape of pancreatic cancer: towards a precision medicine approach

Antonio Pea, Liang Cheng, Claudio Luchini

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Introduction: Pancreatic cancer is a highly malignant disease with an increasing incidence. Most patients with this type of neoplasm present with unresectable tumors at the time of diagnosis. Areas covered: Current treatments for such patients are minimally effective in controlling cancer progression; therefore, alternative therapeutic approaches are needed to improve clinical outcomes. Thanks to the growing body of knowledge on the genetic landscape of pancreatic cancer, the application of the so-called ‘precision medicine’, a new approach that considers the individual variability in molecular alterations to improve oncological outcomes by personalizing cancer treatment, could be now possible for some patients. Expert opinion: In this review, we will discuss the most recent investigative studies, as well as their primary results, of the potential role of precision medicine in the treatment of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)113-119
Number of pages7
JournalExpert Review of Precision Medicine and Drug Development
Volume4
Issue number3
DOIs
StatePublished - May 4 2019

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Keywords

  • Pancreatic cancer
  • cancer genomics
  • molecular alterations
  • personalized treatment
  • precision medicine
  • targeted therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology
  • Drug Discovery

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