Disseminated infection due to rapidly growing mycobacteria in immunocompetent hosts presenting with chronic lymphadenopathy

A previously unrecognized clinical entity

Ploenchan Chetchotisakd, Piroon Mootsikapun, Siriluck Anunnatsiri, Kunya Jirarattanapochai, Charoen Choonhakarn, Angkana Chaiprasert, Preeyawis Na Ubol, L. Joseph Wheat, Thomas Davis

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Disseminated infection due to rapidly growing mycobacteria is uncommon and occurs mostly in immunocompromised patients. We report 16 cases of such infection with an unusual presentation seen at Srinagarind Hospital, a university hospital in northeastern Thailand. The clinical features were different from those in previous reports. All of the patients presented with chronic bilateral cervical lymphadenopathy. Twelve had mycobacterial involvement of other organs (sinuses, 6 patients; lungs, 4; liver, 4; spleen, 3; skin, 3; bone and joint, 2; and tonsils, 2). An interesting occurrence in 11 patients was 14 episodes of reactive skin manifestations (Sweet's syndrome, 9; generalized pustulosis and erythema nodosum, 2 each; and pustular psoriasis, 1). No identifiable predisposing factors, including human immunodeficiency disease, were found in these patients. However, 8 patients had 11 episodes of prior infection or coinfection with other opportunistic pathogens (salmonellosis, 4; penicilliosis, 3; pulmonary tuberculosis, 2; and melioidosis and cryptococcosis, 1 each). These findings suggest that cell- mediated immunity is defective in these patients.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalClinical Infectious Diseases
Volume30
Issue number1
DOIs
StatePublished - 2000

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Mycobacterium
Infection
Sweet Syndrome
Melioidosis
Skin Manifestations
Erythema Nodosum
Cryptococcosis
Salmonella Infections
Palatine Tonsil
Immunocompromised Host
Thailand
Coinfection
Pulmonary Tuberculosis
Psoriasis
Cellular Immunity
Causality
Lymphadenopathy
Spleen
Joints
Bone and Bones

ASJC Scopus subject areas

  • Immunology

Cite this

Disseminated infection due to rapidly growing mycobacteria in immunocompetent hosts presenting with chronic lymphadenopathy : A previously unrecognized clinical entity. / Chetchotisakd, Ploenchan; Mootsikapun, Piroon; Anunnatsiri, Siriluck; Jirarattanapochai, Kunya; Choonhakarn, Charoen; Chaiprasert, Angkana; Na Ubol, Preeyawis; Wheat, L. Joseph; Davis, Thomas.

In: Clinical Infectious Diseases, Vol. 30, No. 1, 2000, p. 29-34.

Research output: Contribution to journalArticle

Chetchotisakd, P, Mootsikapun, P, Anunnatsiri, S, Jirarattanapochai, K, Choonhakarn, C, Chaiprasert, A, Na Ubol, P, Wheat, LJ & Davis, T 2000, 'Disseminated infection due to rapidly growing mycobacteria in immunocompetent hosts presenting with chronic lymphadenopathy: A previously unrecognized clinical entity', Clinical Infectious Diseases, vol. 30, no. 1, pp. 29-34. https://doi.org/10.1086/313589
Chetchotisakd, Ploenchan ; Mootsikapun, Piroon ; Anunnatsiri, Siriluck ; Jirarattanapochai, Kunya ; Choonhakarn, Charoen ; Chaiprasert, Angkana ; Na Ubol, Preeyawis ; Wheat, L. Joseph ; Davis, Thomas. / Disseminated infection due to rapidly growing mycobacteria in immunocompetent hosts presenting with chronic lymphadenopathy : A previously unrecognized clinical entity. In: Clinical Infectious Diseases. 2000 ; Vol. 30, No. 1. pp. 29-34.
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