Disseminated toxoplasmosis resulting in graft failure in a cord blood stem cell transplant recipient

W. Goebel, James H. Conway, Philip Faught, Saeed T. Vakili, Paul Haut

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Toxoplasmosis is an infrequent infection with a high mortality rate in hematopoietic stem cell transplant recipients, and is usually caused by reactivation of prior, latent infection upon intensive immunosuppression. We report a case of fatal disseminated toxoplasmosis, diagnosed at autopsy, in a 7-year-old boy who received a cord blood graft for recurrent acute lymphoblastic leukemia. This case represents both the first reported case of toxoplasmosis in an engrafted cord blood recipient, and also of graft failure due to toxoplasmosis. Recommendations for toxoplasmosis diagnosis, treatment, and prophylaxis in stem cell transplant recipients are reviewed.

Original languageEnglish
Pages (from-to)222-226
Number of pages5
JournalPediatric Blood and Cancer
Volume48
Issue number2
DOIs
StatePublished - Feb 2007

Fingerprint

Toxoplasmosis
Fetal Blood
Blood Cells
Stem Cells
Transplants
Hematopoietic Stem Cells
Infection
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunosuppression
Autopsy
Transplant Recipients
Mortality

Keywords

  • Graft failure
  • Stem cell transplantation
  • Toxoplasmosis
  • Umbilical cord blood

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Disseminated toxoplasmosis resulting in graft failure in a cord blood stem cell transplant recipient. / Goebel, W.; Conway, James H.; Faught, Philip; Vakili, Saeed T.; Haut, Paul.

In: Pediatric Blood and Cancer, Vol. 48, No. 2, 02.2007, p. 222-226.

Research output: Contribution to journalArticle

Goebel, W. ; Conway, James H. ; Faught, Philip ; Vakili, Saeed T. ; Haut, Paul. / Disseminated toxoplasmosis resulting in graft failure in a cord blood stem cell transplant recipient. In: Pediatric Blood and Cancer. 2007 ; Vol. 48, No. 2. pp. 222-226.
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