Disseminated toxoplasmosis resulting in graft failure in a cord blood stem cell transplant recipient

W. Scott Goebel, James H. Conway, Philip Faught, Saeed T. Vakili, Paul R. Haut

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Toxoplasmosis is an infrequent infection with a high mortality rate in hematopoietic stem cell transplant recipients, and is usually caused by reactivation of prior, latent infection upon intensive immunosuppression. We report a case of fatal disseminated toxoplasmosis, diagnosed at autopsy, in a 7-year-old boy who received a cord blood graft for recurrent acute lymphoblastic leukemia. This case represents both the first reported case of toxoplasmosis in an engrafted cord blood recipient, and also of graft failure due to toxoplasmosis. Recommendations for toxoplasmosis diagnosis, treatment, and prophylaxis in stem cell transplant recipients are reviewed.

Original languageEnglish (US)
Pages (from-to)222-226
Number of pages5
JournalPediatric Blood and Cancer
Volume48
Issue number2
DOIs
StatePublished - Feb 1 2007

Keywords

  • Graft failure
  • Stem cell transplantation
  • Toxoplasmosis
  • Umbilical cord blood

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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