Distinction between dysplasia-associated lesion or mass (DALM) and adenoma in patients with ulcerative colitis

Franz Fogt, Stefan J. Urbanski, Melinda E. Sanders, Emma E. Furth, Robert L. Zimmerman, Julius J. Deren, Amy E. Noffsinger, Alexander Vortmeyer, Christopher J. Hartmann, Robert L. Odze, Charlotte A. Brown

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Polyps with epithelial dysplasia in ulcerative colitis (UC) represent either dysplasia-associated lesions or masses (DALMs) or sporadic adenomas. DALMs are frequently associated with associated carcinoma and are an indication for colectomy. Removal of the polyp is treatment of choice for sporadic adenomas. Differentiating between these 2 lesions is not always easy. The goal of this study was to distinguish DALMs from adenomas in patients with UC on a genetic basis. We evaluated genetic alterations in DALMs and compared them with a previously published set of dysplastic polyps in patients with UC that were considered adenomas for the following reasons: (1) polyps were located outside of current active disease; (2) polyps had histological features of sporadic adenomas; and (3) patients displayed a uneventful follow-up after polypectomy (UC-adenomas). In addition, adenomas not associated with UC were studied. Genetic alterations on chromosome 3p were assessed for the markers D3S1766, D3S2409, and D3S2387. LOH with or without microsatellite instability was found in 70%, 37%, and 57% of cases of DALM, respectively. In contrast, UC-adenomas lesions exhibited genetic alterations in 8.3%, 11.7%, and 15.3% for the respective markers. Spontaneous adenomas exhibited genetic alterations in 10.5%, 7.1%, and 0% of cases, which were not significantly different from the UC-adenoma results. These results indicate that UC-adenomas are genetically and biologically similar to sporadic adenomas and that UC-adenomas may biologically represent sporadic adenomas, supporting on a genetic basis the criteria chosen to diagnose adenomas in UC. Genetic markers on chromosome 3p may be useful in the differential diagnosis between DALM and UC-adenomas. (C) 2000 by W.B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)288-291
Number of pages4
JournalHuman Pathology
Volume31
Issue number3
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Ulcerative Colitis
Adenoma
Polyps
Chromosomes
Microsatellite Instability
Colectomy
Genetic Markers
Differential Diagnosis

Keywords

  • Adenoma
  • DALM
  • Dysplasia
  • Microdissection
  • Molecular pathology
  • Ulcerative colitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Fogt, F., Urbanski, S. J., Sanders, M. E., Furth, E. E., Zimmerman, R. L., Deren, J. J., ... Brown, C. A. (2000). Distinction between dysplasia-associated lesion or mass (DALM) and adenoma in patients with ulcerative colitis. Human Pathology, 31(3), 288-291. https://doi.org/10.1016/S0046-8177(00)80240-3

Distinction between dysplasia-associated lesion or mass (DALM) and adenoma in patients with ulcerative colitis. / Fogt, Franz; Urbanski, Stefan J.; Sanders, Melinda E.; Furth, Emma E.; Zimmerman, Robert L.; Deren, Julius J.; Noffsinger, Amy E.; Vortmeyer, Alexander; Hartmann, Christopher J.; Odze, Robert L.; Brown, Charlotte A.

In: Human Pathology, Vol. 31, No. 3, 01.01.2000, p. 288-291.

Research output: Contribution to journalArticle

Fogt, F, Urbanski, SJ, Sanders, ME, Furth, EE, Zimmerman, RL, Deren, JJ, Noffsinger, AE, Vortmeyer, A, Hartmann, CJ, Odze, RL & Brown, CA 2000, 'Distinction between dysplasia-associated lesion or mass (DALM) and adenoma in patients with ulcerative colitis', Human Pathology, vol. 31, no. 3, pp. 288-291. https://doi.org/10.1016/S0046-8177(00)80240-3
Fogt, Franz ; Urbanski, Stefan J. ; Sanders, Melinda E. ; Furth, Emma E. ; Zimmerman, Robert L. ; Deren, Julius J. ; Noffsinger, Amy E. ; Vortmeyer, Alexander ; Hartmann, Christopher J. ; Odze, Robert L. ; Brown, Charlotte A. / Distinction between dysplasia-associated lesion or mass (DALM) and adenoma in patients with ulcerative colitis. In: Human Pathology. 2000 ; Vol. 31, No. 3. pp. 288-291.
@article{6c5b3ebea7d348e68807c2e1263ac6f2,
title = "Distinction between dysplasia-associated lesion or mass (DALM) and adenoma in patients with ulcerative colitis",
abstract = "Polyps with epithelial dysplasia in ulcerative colitis (UC) represent either dysplasia-associated lesions or masses (DALMs) or sporadic adenomas. DALMs are frequently associated with associated carcinoma and are an indication for colectomy. Removal of the polyp is treatment of choice for sporadic adenomas. Differentiating between these 2 lesions is not always easy. The goal of this study was to distinguish DALMs from adenomas in patients with UC on a genetic basis. We evaluated genetic alterations in DALMs and compared them with a previously published set of dysplastic polyps in patients with UC that were considered adenomas for the following reasons: (1) polyps were located outside of current active disease; (2) polyps had histological features of sporadic adenomas; and (3) patients displayed a uneventful follow-up after polypectomy (UC-adenomas). In addition, adenomas not associated with UC were studied. Genetic alterations on chromosome 3p were assessed for the markers D3S1766, D3S2409, and D3S2387. LOH with or without microsatellite instability was found in 70{\%}, 37{\%}, and 57{\%} of cases of DALM, respectively. In contrast, UC-adenomas lesions exhibited genetic alterations in 8.3{\%}, 11.7{\%}, and 15.3{\%} for the respective markers. Spontaneous adenomas exhibited genetic alterations in 10.5{\%}, 7.1{\%}, and 0{\%} of cases, which were not significantly different from the UC-adenoma results. These results indicate that UC-adenomas are genetically and biologically similar to sporadic adenomas and that UC-adenomas may biologically represent sporadic adenomas, supporting on a genetic basis the criteria chosen to diagnose adenomas in UC. Genetic markers on chromosome 3p may be useful in the differential diagnosis between DALM and UC-adenomas. (C) 2000 by W.B. Saunders Company.",
keywords = "Adenoma, DALM, Dysplasia, Microdissection, Molecular pathology, Ulcerative colitis",
author = "Franz Fogt and Urbanski, {Stefan J.} and Sanders, {Melinda E.} and Furth, {Emma E.} and Zimmerman, {Robert L.} and Deren, {Julius J.} and Noffsinger, {Amy E.} and Alexander Vortmeyer and Hartmann, {Christopher J.} and Odze, {Robert L.} and Brown, {Charlotte A.}",
year = "2000",
month = "1",
day = "1",
doi = "10.1016/S0046-8177(00)80240-3",
language = "English (US)",
volume = "31",
pages = "288--291",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Distinction between dysplasia-associated lesion or mass (DALM) and adenoma in patients with ulcerative colitis

AU - Fogt, Franz

AU - Urbanski, Stefan J.

AU - Sanders, Melinda E.

AU - Furth, Emma E.

AU - Zimmerman, Robert L.

AU - Deren, Julius J.

AU - Noffsinger, Amy E.

AU - Vortmeyer, Alexander

AU - Hartmann, Christopher J.

AU - Odze, Robert L.

AU - Brown, Charlotte A.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Polyps with epithelial dysplasia in ulcerative colitis (UC) represent either dysplasia-associated lesions or masses (DALMs) or sporadic adenomas. DALMs are frequently associated with associated carcinoma and are an indication for colectomy. Removal of the polyp is treatment of choice for sporadic adenomas. Differentiating between these 2 lesions is not always easy. The goal of this study was to distinguish DALMs from adenomas in patients with UC on a genetic basis. We evaluated genetic alterations in DALMs and compared them with a previously published set of dysplastic polyps in patients with UC that were considered adenomas for the following reasons: (1) polyps were located outside of current active disease; (2) polyps had histological features of sporadic adenomas; and (3) patients displayed a uneventful follow-up after polypectomy (UC-adenomas). In addition, adenomas not associated with UC were studied. Genetic alterations on chromosome 3p were assessed for the markers D3S1766, D3S2409, and D3S2387. LOH with or without microsatellite instability was found in 70%, 37%, and 57% of cases of DALM, respectively. In contrast, UC-adenomas lesions exhibited genetic alterations in 8.3%, 11.7%, and 15.3% for the respective markers. Spontaneous adenomas exhibited genetic alterations in 10.5%, 7.1%, and 0% of cases, which were not significantly different from the UC-adenoma results. These results indicate that UC-adenomas are genetically and biologically similar to sporadic adenomas and that UC-adenomas may biologically represent sporadic adenomas, supporting on a genetic basis the criteria chosen to diagnose adenomas in UC. Genetic markers on chromosome 3p may be useful in the differential diagnosis between DALM and UC-adenomas. (C) 2000 by W.B. Saunders Company.

AB - Polyps with epithelial dysplasia in ulcerative colitis (UC) represent either dysplasia-associated lesions or masses (DALMs) or sporadic adenomas. DALMs are frequently associated with associated carcinoma and are an indication for colectomy. Removal of the polyp is treatment of choice for sporadic adenomas. Differentiating between these 2 lesions is not always easy. The goal of this study was to distinguish DALMs from adenomas in patients with UC on a genetic basis. We evaluated genetic alterations in DALMs and compared them with a previously published set of dysplastic polyps in patients with UC that were considered adenomas for the following reasons: (1) polyps were located outside of current active disease; (2) polyps had histological features of sporadic adenomas; and (3) patients displayed a uneventful follow-up after polypectomy (UC-adenomas). In addition, adenomas not associated with UC were studied. Genetic alterations on chromosome 3p were assessed for the markers D3S1766, D3S2409, and D3S2387. LOH with or without microsatellite instability was found in 70%, 37%, and 57% of cases of DALM, respectively. In contrast, UC-adenomas lesions exhibited genetic alterations in 8.3%, 11.7%, and 15.3% for the respective markers. Spontaneous adenomas exhibited genetic alterations in 10.5%, 7.1%, and 0% of cases, which were not significantly different from the UC-adenoma results. These results indicate that UC-adenomas are genetically and biologically similar to sporadic adenomas and that UC-adenomas may biologically represent sporadic adenomas, supporting on a genetic basis the criteria chosen to diagnose adenomas in UC. Genetic markers on chromosome 3p may be useful in the differential diagnosis between DALM and UC-adenomas. (C) 2000 by W.B. Saunders Company.

KW - Adenoma

KW - DALM

KW - Dysplasia

KW - Microdissection

KW - Molecular pathology

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=0034118420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034118420&partnerID=8YFLogxK

U2 - 10.1016/S0046-8177(00)80240-3

DO - 10.1016/S0046-8177(00)80240-3

M3 - Article

C2 - 10746669

AN - SCOPUS:0034118420

VL - 31

SP - 288

EP - 291

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 3

ER -