Distinctive Acid-Base Pattern in Wernicke's Encephalopathy

Michael W. Donnino, Joseph Miller, A. Joseph Garcia, Edward McKee, Mark Walsh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Wernicke's encephalopathy may result in severe morbidity and possible mortality when unrecognized. We report a distinctive acid-base pattern that has not been associated with this syndrome. This is a case series of patients with Wernicke's encephalopathy who had an arterial blood gas measurement performed on initial presentation. Exclusion criteria were patients with an unclear diagnosis of Wernicke's encephalopathy and those for whom no arterial blood gas measurement was performed. Four patients with Wernicke's encephalopathy were included in the analysis. All 4 patients exhibited an anion-gap (primary) metabolic acidosis, accompanied by a primary respiratory alkalosis. Three of 4 patients exhibited a significant lactic acidosis. None of the patients had any competing diagnoses or dysfunction to account for this acid-base pattern. Patients with Wernicke's encephalopathy may exhibit a distinctive acid-base pattern consisting of a primary metabolic acidosis in conjunction with a primary respiratory alkalosis. Observation of this acid-base disturbance should prompt clinicians to consider thiamine deficiency disorders as a possible cause.

Original languageEnglish (US)
Pages (from-to)722-725
Number of pages4
JournalAnnals of Emergency Medicine
Volume50
Issue number6
DOIs
StatePublished - Dec 1 2007

Fingerprint

Wernicke Encephalopathy
Acids
Respiratory Alkalosis
Acidosis
Gases
Thiamine Deficiency
Lactic Acidosis
Acid-Base Equilibrium
Observation
Morbidity
Mortality

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Donnino, M. W., Miller, J., Garcia, A. J., McKee, E., & Walsh, M. (2007). Distinctive Acid-Base Pattern in Wernicke's Encephalopathy. Annals of Emergency Medicine, 50(6), 722-725. https://doi.org/10.1016/j.annemergmed.2006.10.022

Distinctive Acid-Base Pattern in Wernicke's Encephalopathy. / Donnino, Michael W.; Miller, Joseph; Garcia, A. Joseph; McKee, Edward; Walsh, Mark.

In: Annals of Emergency Medicine, Vol. 50, No. 6, 01.12.2007, p. 722-725.

Research output: Contribution to journalArticle

Donnino, MW, Miller, J, Garcia, AJ, McKee, E & Walsh, M 2007, 'Distinctive Acid-Base Pattern in Wernicke's Encephalopathy', Annals of Emergency Medicine, vol. 50, no. 6, pp. 722-725. https://doi.org/10.1016/j.annemergmed.2006.10.022
Donnino, Michael W. ; Miller, Joseph ; Garcia, A. Joseph ; McKee, Edward ; Walsh, Mark. / Distinctive Acid-Base Pattern in Wernicke's Encephalopathy. In: Annals of Emergency Medicine. 2007 ; Vol. 50, No. 6. pp. 722-725.
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