Distribution of local repolarization changes produced by efferent vagal stimulation in the canine ventricles

J. B. Martins, D. P. Zipes, D. D. Lund

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The purpose of this study was to compare the distribution of effects of right and left efferent vagal stimulation on ventricular recovery properties in the in situ heart. To measure these effects in many areas simultaneously, local repolarization changes (local QT intervals) were recorded with bipolar electrodes in nine ventricular sites from 38 anaesthetized dogs. In initial experiments, this method was shown to correlate with effective refractory period changes measured in the same test site after QT recording; vagal nerve stimulation prolonged the local QT interval by 1 ms for each 0.82 ms prolongation in effective refractory period (r = 0.87). Simultaneous local QT recordings during vagal nerve stimulation demonstrated uniform prolongation with two exceptions. First, left vagal efferent stimulation prolonged local QT interval in the posterior left ventricular base more than did right vagal stimulation (5.9 ± 1.0 mean ± standard error of the mean versus 3.7 ± 0.9%, p <0.05). This probably resulted from an interaction with the left sympathetic nerves because left stellate ganglionectomy or norepinephrine infusion eliminated differences between effects of right and left vagal stimulation. Second, it was also found that vagal stimulation from either side did not prolong local QT interval time in the anterior right ventricle despite attempts to augment vagal effects with bilateral vagal stimulation alone or during isoproterenol or physostigmine administration. These regional differences in ventricular repolarization exhibited in response to efferent vagal nerve stimulation in the dog may provide a basis for understanding how autonomic influences could contribute to the genesis of ventricular arrhythmias.

Original languageEnglish (US)
Pages (from-to)1191-1199
Number of pages9
JournalJournal of the American College of Cardiology
Volume2
Issue number6
StatePublished - 1983
Externally publishedYes

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Vagus Nerve Stimulation
Canidae
Ganglionectomy
Dogs
Physostigmine
Isoproterenol
Heart Ventricles
Cardiac Arrhythmias
Norepinephrine
Electrodes

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Distribution of local repolarization changes produced by efferent vagal stimulation in the canine ventricles. / Martins, J. B.; Zipes, D. P.; Lund, D. D.

In: Journal of the American College of Cardiology, Vol. 2, No. 6, 1983, p. 1191-1199.

Research output: Contribution to journalArticle

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