Distribution of myocardial glucose consumption under normal conditions and during isoprenaline and dobutamine infusion.

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Abstract

The regional myocardial metabolic rate of glucose (reg. MMR Gl) of the left ventricular free wall was determined applying the 2-deoxyglucose method (Sokoloff, 1977) in the anesthetized closed chest dog. Under control conditions an inhomogeneous distribution of MMR Gl was observed. Isoprenaline or dobutamine infusions resulted in a redistribution of MMR Gl. With isoprenaline a homogeneous distribution pattern was observed, while with dobutamine a slight decrease in MMR Gl of the subendocardial region was measured. This redistribution may result from altered ventricular working conditions, due to changes in ventricular volumes or from differences in the frequency of myocardial adrenoceptors within the ventricular wall.

Original languageEnglish
Pages (from-to)369-380
Number of pages12
JournalAdvances in Experimental Medicine and Biology
Volume169
StatePublished - 1984
Externally publishedYes

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Dobutamine
Isoproterenol
Glucose
Deoxyglucose
Adrenergic Receptors
Thorax
Dogs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "The regional myocardial metabolic rate of glucose (reg. MMR Gl) of the left ventricular free wall was determined applying the 2-deoxyglucose method (Sokoloff, 1977) in the anesthetized closed chest dog. Under control conditions an inhomogeneous distribution of MMR Gl was observed. Isoprenaline or dobutamine infusions resulted in a redistribution of MMR Gl. With isoprenaline a homogeneous distribution pattern was observed, while with dobutamine a slight decrease in MMR Gl of the subendocardial region was measured. This redistribution may result from altered ventricular working conditions, due to changes in ventricular volumes or from differences in the frequency of myocardial adrenoceptors within the ventricular wall.",
author = "W. Breull and {Rubart-von der Lohe}, Michael",
year = "1984",
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volume = "169",
pages = "369--380",
journal = "Advances in Experimental Medicine and Biology",
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AU - Breull, W.

AU - Rubart-von der Lohe, Michael

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N2 - The regional myocardial metabolic rate of glucose (reg. MMR Gl) of the left ventricular free wall was determined applying the 2-deoxyglucose method (Sokoloff, 1977) in the anesthetized closed chest dog. Under control conditions an inhomogeneous distribution of MMR Gl was observed. Isoprenaline or dobutamine infusions resulted in a redistribution of MMR Gl. With isoprenaline a homogeneous distribution pattern was observed, while with dobutamine a slight decrease in MMR Gl of the subendocardial region was measured. This redistribution may result from altered ventricular working conditions, due to changes in ventricular volumes or from differences in the frequency of myocardial adrenoceptors within the ventricular wall.

AB - The regional myocardial metabolic rate of glucose (reg. MMR Gl) of the left ventricular free wall was determined applying the 2-deoxyglucose method (Sokoloff, 1977) in the anesthetized closed chest dog. Under control conditions an inhomogeneous distribution of MMR Gl was observed. Isoprenaline or dobutamine infusions resulted in a redistribution of MMR Gl. With isoprenaline a homogeneous distribution pattern was observed, while with dobutamine a slight decrease in MMR Gl of the subendocardial region was measured. This redistribution may result from altered ventricular working conditions, due to changes in ventricular volumes or from differences in the frequency of myocardial adrenoceptors within the ventricular wall.

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