Distribution of several amino acids in regions of the cerebellum of the rat

N. S. NADI, W. J. MBRIDE, M. H. APRISON

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Abstract

The present study was undertaken to determine the distribution of several putative neurotransmitter amino acids in the layers of the cerebellum of the normal rat, in order to check the hypothesis that glutamate is localized in the granule cells, and taurine is localized in the stellate cells. The levels of glutamate in the molecular and granular layers were approximately equal and were nearly 3-fold greater than the values found in the white matter and deep nuclei. The level of taurine is significantly higher in the molecular layer than in the other regions of the cerebellum. The highest level of GABA was found in the deep nuclei. The content of glycine is lowest in the white matter which contains the afferent fibers to the cerebellar cortex and the Purkinje cell axons, which are the major efferent fibers from the cerebellar cortex. The level of glycine is approximately the same in the other regions. The levels of aspartate in the molecular and granular layers were approximately the same and slightly higher than the values found in the deep nuclei. The value for aspartate was lowest in the white matter and approximately one half that found in the deep nuclei. The distribution of alanine was also uneven, with the highest levels found in the molecular and granular layers and the lowest in the white region and deep nuclei.

Original languageEnglish (US)
Pages (from-to)453-455
Number of pages3
JournalJournal of Neurochemistry
Volume28
Issue number2
DOIs
StatePublished - Feb 1977

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ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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