Distribution of Vaccine-Type Human Papillomavirus Does Not Differ by Race or Ethnicity among Unvaccinated Young Women

Dana Whittemore, Lili Ding, Lea E. Widdice, Darron Brown, David I. Bernstein, Eduardo L. Franco, Jessica A. Kahn

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Previous studies have demonstrated racial and ethnic differences in the distribution of human papillomavirus (HPV) types among adult women with cervical precancers. The aim of this study was to determine whether the distribution of vaccine-targeted HPV types varies by race/ethnicity among unvaccinated young women. Materials and Methods: A secondary analysis was performed using data from four studies of sexually experienced, unvaccinated, 13-26-year-old women. Participants completed surveys and provided a cervicovaginal swab for HPV DNA testing. Multivariable logistic regression analyses were performed to examine whether race, ethnicity, and other factors were associated with type-specific HPV infection among the overall sample and among HPV-infected participants. Models controlled for age, HPV knowledge, sexual behaviors, substance use, and random study effect. Results: The mean age of participants (N = 841) was 19.3 years; 64.4% were black and 8.9% Hispanic. Black women were more likely than white women to be positive for ≥1 HPV type (odds ratio [OR] 1.83, 95% CI 1.30-2.58) and Hispanic women were less likely than non-Hispanic women to be positive for ≥1 HPV type (OR 0.47, 95% CI 0.24-0.92). However, among all young women and HPV-infected women, neither race nor ethnicity was associated with positivity for HPV types targeted by the following vaccines: 2-valent (HPV16 and/or 18), 4-valent (HPV6, 11, 16, and/or 18), or 9-valent (HPV6, 11, 16, 18, 31, 33, 45, 52, and/or 58). Conclusion: The prevalence of HPV types targeted by the 2-valent, 4-valent, and 9-valent vaccines did not differ by race or ethnicity among all and among HPV-infected women in this sample.

Original languageEnglish (US)
Pages (from-to)1153-1158
Number of pages6
JournalJournal of Women's Health
Volume25
Issue number11
DOIs
StatePublished - Nov 1 2016

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Papillomavirus Vaccines
Hispanic Americans
Vaccines
Odds Ratio
Papillomavirus Infections
Sexual Behavior
Logistic Models
Regression Analysis

Keywords

  • epidemiology
  • ethnicity
  • human papillomavirus
  • Race
  • vaccine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Distribution of Vaccine-Type Human Papillomavirus Does Not Differ by Race or Ethnicity among Unvaccinated Young Women. / Whittemore, Dana; Ding, Lili; Widdice, Lea E.; Brown, Darron; Bernstein, David I.; Franco, Eduardo L.; Kahn, Jessica A.

In: Journal of Women's Health, Vol. 25, No. 11, 01.11.2016, p. 1153-1158.

Research output: Contribution to journalArticle

Whittemore, Dana ; Ding, Lili ; Widdice, Lea E. ; Brown, Darron ; Bernstein, David I. ; Franco, Eduardo L. ; Kahn, Jessica A. / Distribution of Vaccine-Type Human Papillomavirus Does Not Differ by Race or Ethnicity among Unvaccinated Young Women. In: Journal of Women's Health. 2016 ; Vol. 25, No. 11. pp. 1153-1158.
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abstract = "Background: Previous studies have demonstrated racial and ethnic differences in the distribution of human papillomavirus (HPV) types among adult women with cervical precancers. The aim of this study was to determine whether the distribution of vaccine-targeted HPV types varies by race/ethnicity among unvaccinated young women. Materials and Methods: A secondary analysis was performed using data from four studies of sexually experienced, unvaccinated, 13-26-year-old women. Participants completed surveys and provided a cervicovaginal swab for HPV DNA testing. Multivariable logistic regression analyses were performed to examine whether race, ethnicity, and other factors were associated with type-specific HPV infection among the overall sample and among HPV-infected participants. Models controlled for age, HPV knowledge, sexual behaviors, substance use, and random study effect. Results: The mean age of participants (N = 841) was 19.3 years; 64.4{\%} were black and 8.9{\%} Hispanic. Black women were more likely than white women to be positive for ≥1 HPV type (odds ratio [OR] 1.83, 95{\%} CI 1.30-2.58) and Hispanic women were less likely than non-Hispanic women to be positive for ≥1 HPV type (OR 0.47, 95{\%} CI 0.24-0.92). However, among all young women and HPV-infected women, neither race nor ethnicity was associated with positivity for HPV types targeted by the following vaccines: 2-valent (HPV16 and/or 18), 4-valent (HPV6, 11, 16, and/or 18), or 9-valent (HPV6, 11, 16, 18, 31, 33, 45, 52, and/or 58). Conclusion: The prevalence of HPV types targeted by the 2-valent, 4-valent, and 9-valent vaccines did not differ by race or ethnicity among all and among HPV-infected women in this sample.",
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T1 - Distribution of Vaccine-Type Human Papillomavirus Does Not Differ by Race or Ethnicity among Unvaccinated Young Women

AU - Whittemore, Dana

AU - Ding, Lili

AU - Widdice, Lea E.

AU - Brown, Darron

AU - Bernstein, David I.

AU - Franco, Eduardo L.

AU - Kahn, Jessica A.

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AB - Background: Previous studies have demonstrated racial and ethnic differences in the distribution of human papillomavirus (HPV) types among adult women with cervical precancers. The aim of this study was to determine whether the distribution of vaccine-targeted HPV types varies by race/ethnicity among unvaccinated young women. Materials and Methods: A secondary analysis was performed using data from four studies of sexually experienced, unvaccinated, 13-26-year-old women. Participants completed surveys and provided a cervicovaginal swab for HPV DNA testing. Multivariable logistic regression analyses were performed to examine whether race, ethnicity, and other factors were associated with type-specific HPV infection among the overall sample and among HPV-infected participants. Models controlled for age, HPV knowledge, sexual behaviors, substance use, and random study effect. Results: The mean age of participants (N = 841) was 19.3 years; 64.4% were black and 8.9% Hispanic. Black women were more likely than white women to be positive for ≥1 HPV type (odds ratio [OR] 1.83, 95% CI 1.30-2.58) and Hispanic women were less likely than non-Hispanic women to be positive for ≥1 HPV type (OR 0.47, 95% CI 0.24-0.92). However, among all young women and HPV-infected women, neither race nor ethnicity was associated with positivity for HPV types targeted by the following vaccines: 2-valent (HPV16 and/or 18), 4-valent (HPV6, 11, 16, and/or 18), or 9-valent (HPV6, 11, 16, 18, 31, 33, 45, 52, and/or 58). Conclusion: The prevalence of HPV types targeted by the 2-valent, 4-valent, and 9-valent vaccines did not differ by race or ethnicity among all and among HPV-infected women in this sample.

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