DNA repair as an emerging target for COPD-lung cancer overlap

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cigarette smoking is the leading cause of lung cancer and chronic obstructive pulmonary disease (COPD). Many of the detrimental effects of cigarette smoke have been attributed to the development of DNA damage, either directly from chemicals contained in cigarette smoke or as a product of cigarette smoke-induced inflammation and oxidative stress. In this review, we discuss the environmental, epidemiological, and physiological links between COPD and lung cancer and the likely role of DNA damage and repair in COPD and lung cancer development. We explore alterations in DNA damage repair by DNA repair proteins and pathways. We discuss emerging data supporting a key role for the DNA repair protein, xeroderma pigmentosum group C (XPC), in cigarette smoke-induced COPD and early lung cancer development. Understanding the interplay between cigarette smoke, DNA damage repair, COPD, and lung cancer may lead to prognostic tools and new, potentially targetable, pathways for lung cancer prevention and treatment.

Original languageEnglish (US)
JournalRespiratory Investigation
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

DNA Repair
Chronic Obstructive Pulmonary Disease
Lung Neoplasms
Smoke
Tobacco Products
DNA Damage
Xeroderma Pigmentosum
Proteins
Oxidative Stress
Smoking
Inflammation

Keywords

  • Cigarette smoke
  • Emphysema
  • Mutations
  • Nucleotide excision repair
  • Oxidative stress

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

DNA repair as an emerging target for COPD-lung cancer overlap. / Sears, Catherine.

In: Respiratory Investigation, 01.01.2019.

Research output: Contribution to journalArticle

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