DNA repair in cancer therapy

Research output: Book/ReportBook

13 Citations (Scopus)

Abstract

Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, and overcoming this drug resistance is an important research focus. Additionally, increasing discussion and research is centering on targeted and individualized therapy. While a number of approaches have undergone intensive and close scrutiny as potential approaches to treat and kill cancer (signaling pathways, multidrug resistance, cell cycle checkpoints, anti-angiogenesis, etc.), other approaches have focused on blocking the ability of a cancer cell to recognize and repair the damaged DNA that primarily results from the front-line cancer treatments; chemotherapy and radiation. This comprehensive and timely reference focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on DNA repair and cancer therapy, as opposed to searching through thousands of journal articles Provides a common language for cancer researchers, oncologists, and radiation oncologists to discuss their understanding of new molecular pathways, clinical targets, and anti-cancer drug development Provides content for researchers and research clinicians to understand the importance of the breakthroughs that are contributing to advances in disease-specific research.

Original languageEnglish (US)
PublisherElsevier Inc.
ISBN (Print)9780123849991
DOIs
StatePublished - 2012

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DNA Repair
Neoplasms
Therapeutics
Research Personnel
Research
Drug Therapy
Aptitude
Critical Pathways
Multiple Drug Resistance
Tumor Biomarkers
Cell Cycle Checkpoints
Drug Resistance
Language
Radiotherapy
Radiation

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

Cite this

DNA repair in cancer therapy. / Kelley, Mark.

Elsevier Inc., 2012.

Research output: Book/ReportBook

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