Do epigenetic marks govern bone mass and homeostasis?

Jesús Delgado-Calle, Pablo Garmilla, José A. Riancho

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Bone is a specialized connective tissue with a calcified extracellular matrix in which cells are embedded. Besides providing the internal support of the body and protection for vital organs, bone also has several important metabolic functions, especially in mineral homeostasis. Far from being a passive tissue, it is continuously being resorbed and formed again throughout life, by a process known as bone remodeling. Bone development and remodeling are influenced by many factors, some of which may be modifiable in the early steps of life. Several studies have shown that environmental factors in uterus and in infancy may modify the skeletal growth pattern, influencing the risk of bone disease in later life. On the other hand, bone remodeling is a highly orchestrated multicellular process that requires the sequential and balanced events of osteoclast-mediated bone resorption and osteoblast-mediated bone formation. These processes are accompanied by specific gene expression patterns which are responsible for the differentiation of the mesenchymal and hematopoietic precursors of osteoblasts and osteoclasts, respectively, and the activity of differentiated bone cells. This review summarizes the current understanding of how epigenetic mechanisms influence these processes and their possible role in common skeletal diseases.

Original languageEnglish (US)
Pages (from-to)252-263
Number of pages12
JournalCurrent Genomics
Volume13
Issue number3
DOIs
StatePublished - May 2012
Externally publishedYes

Keywords

  • DNA methylation
  • Gene expression
  • Histones
  • Osteoblasts
  • Osteoclasts
  • Osteoporosis
  • miRNA

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Do epigenetic marks govern bone mass and homeostasis?'. Together they form a unique fingerprint.

  • Cite this

    Delgado-Calle, J., Garmilla, P., & Riancho, J. A. (2012). Do epigenetic marks govern bone mass and homeostasis? Current Genomics, 13(3), 252-263. https://doi.org/10.2174/138920212800543129