Do epigenetic marks govern bone mass and homeostasis?

Jesus Delgado-Calle, Pablo Garmilla, José A. Riancho

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Bone is a specialized connective tissue with a calcified extracellular matrix in which cells are embedded. Besides providing the internal support of the body and protection for vital organs, bone also has several important metabolic functions, especially in mineral homeostasis. Far from being a passive tissue, it is continuously being resorbed and formed again throughout life, by a process known as bone remodeling. Bone development and remodeling are influenced by many factors, some of which may be modifiable in the early steps of life. Several studies have shown that environmental factors in uterus and in infancy may modify the skeletal growth pattern, influencing the risk of bone disease in later life. On the other hand, bone remodeling is a highly orchestrated multicellular process that requires the sequential and balanced events of osteoclast-mediated bone resorption and osteoblast-mediated bone formation. These processes are accompanied by specific gene expression patterns which are responsible for the differentiation of the mesenchymal and hematopoietic precursors of osteoblasts and osteoclasts, respectively, and the activity of differentiated bone cells. This review summarizes the current understanding of how epigenetic mechanisms influence these processes and their possible role in common skeletal diseases.

Original languageEnglish (US)
Pages (from-to)252-263
Number of pages12
JournalCurrent Genomics
Volume13
Issue number3
StatePublished - May 2012
Externally publishedYes

Fingerprint

Bone Remodeling
Epigenomics
Homeostasis
Osteoclasts
Osteoblasts
Bone and Bones
Hand Bones
Bone Diseases
Bone Development
Bone Resorption
Osteogenesis
Connective Tissue
Uterus
Extracellular Matrix
Minerals
Gene Expression
Growth

Keywords

  • DNA methylation
  • Gene expression
  • Histones
  • miRNA
  • Osteoblasts
  • Osteoclasts
  • Osteoporosis

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Delgado-Calle, J., Garmilla, P., & Riancho, J. A. (2012). Do epigenetic marks govern bone mass and homeostasis? Current Genomics, 13(3), 252-263.

Do epigenetic marks govern bone mass and homeostasis? / Delgado-Calle, Jesus; Garmilla, Pablo; Riancho, José A.

In: Current Genomics, Vol. 13, No. 3, 05.2012, p. 252-263.

Research output: Contribution to journalArticle

Delgado-Calle, J, Garmilla, P & Riancho, JA 2012, 'Do epigenetic marks govern bone mass and homeostasis?', Current Genomics, vol. 13, no. 3, pp. 252-263.
Delgado-Calle, Jesus ; Garmilla, Pablo ; Riancho, José A. / Do epigenetic marks govern bone mass and homeostasis?. In: Current Genomics. 2012 ; Vol. 13, No. 3. pp. 252-263.
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