Dobutamine stress echocardiography: Causes and approach to false negative and false positive studies

Research output: Contribution to journalComment/debate

2 Scopus citations


Dobumitamine stress echocardiography has clinically useful levels of sensitivity and specificity. False negative studies are more common in patients with single vessel disease and those not achieving adequate levels of stress. Adequate stress can be attained in more patients with the use of atropine and aggressive dobutamine infusion protocols. Digital storage and display of baseline and serial stress images assists in the recognition of subtle or atypical manifestations of ischemia. A variety of cardiac conditions can produce baseline wall motion abnormalities in the absence of significant coronary artery disease. These conditions can often be identified before stress testing is performed. Dobutamine-induced wall motion abnormalities may occur in the absence of significant coronary obstruction. Myocardial ischemia remains a potential cause of these false positive studies, particularly when two or more conditions that reduce perfusion reserve are present.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalACC Current Journal Review
Issue number3
StatePublished - Jan 1 1995


ASJC Scopus subject areas

  • Nursing(all)
  • Cardiology and Cardiovascular Medicine

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