Does intratubular germ cell neoplasia, unclassified type exist in prepubertal, cryptorchid testes?

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Six of 276 prepubertal testicular specimens had atypical germ cells. Specimens from 3 intersex patients met the criteria for intratubular germ cell neoplasia, unclassified type (IGCNU). Of the remaining 3 specimens (2 patients), 1 from a Down syndrome patient had centrally positioned germ cells with mild nuclear enlargement and hyperchromasia and expressed fetal germ cell markers (Oct3/4, placental alkaline phosphatase, CD117); it was classified as "delayed germ cell maturation". The remaining 2 specimens (1 patient) were diagnosed as IGCNU but, in retrospect, the patient had an undiagnosed intersex disorder. We therefore did not find a bona fide case of IGCNU in prepubertal testes apart from an intersex disorder.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalFetal and Pediatric Pathology
Volume31
Issue number1
DOIs
StatePublished - Feb 2012

Fingerprint

Germ Cells
Testis
Neoplasms
Down Syndrome

Keywords

  • IGCNU
  • Intratubular germ cell neoplasia
  • Prepubertal
  • Testis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

@article{2333e1e6b8364f1cb2e35381937e1e56,
title = "Does intratubular germ cell neoplasia, unclassified type exist in prepubertal, cryptorchid testes?",
abstract = "Six of 276 prepubertal testicular specimens had atypical germ cells. Specimens from 3 intersex patients met the criteria for intratubular germ cell neoplasia, unclassified type (IGCNU). Of the remaining 3 specimens (2 patients), 1 from a Down syndrome patient had centrally positioned germ cells with mild nuclear enlargement and hyperchromasia and expressed fetal germ cell markers (Oct3/4, placental alkaline phosphatase, CD117); it was classified as {"}delayed germ cell maturation{"}. The remaining 2 specimens (1 patient) were diagnosed as IGCNU but, in retrospect, the patient had an undiagnosed intersex disorder. We therefore did not find a bona fide case of IGCNU in prepubertal testes apart from an intersex disorder.",
keywords = "IGCNU, Intratubular germ cell neoplasia, Prepubertal, Testis",
author = "Rong Fan and Thomas Ulbright",
year = "2012",
month = "2",
doi = "10.3109/15513815.2011.618874",
language = "English",
volume = "31",
pages = "21--24",
journal = "Fetal and Pediatric Pathology",
issn = "1551-3815",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Does intratubular germ cell neoplasia, unclassified type exist in prepubertal, cryptorchid testes?

AU - Fan, Rong

AU - Ulbright, Thomas

PY - 2012/2

Y1 - 2012/2

N2 - Six of 276 prepubertal testicular specimens had atypical germ cells. Specimens from 3 intersex patients met the criteria for intratubular germ cell neoplasia, unclassified type (IGCNU). Of the remaining 3 specimens (2 patients), 1 from a Down syndrome patient had centrally positioned germ cells with mild nuclear enlargement and hyperchromasia and expressed fetal germ cell markers (Oct3/4, placental alkaline phosphatase, CD117); it was classified as "delayed germ cell maturation". The remaining 2 specimens (1 patient) were diagnosed as IGCNU but, in retrospect, the patient had an undiagnosed intersex disorder. We therefore did not find a bona fide case of IGCNU in prepubertal testes apart from an intersex disorder.

AB - Six of 276 prepubertal testicular specimens had atypical germ cells. Specimens from 3 intersex patients met the criteria for intratubular germ cell neoplasia, unclassified type (IGCNU). Of the remaining 3 specimens (2 patients), 1 from a Down syndrome patient had centrally positioned germ cells with mild nuclear enlargement and hyperchromasia and expressed fetal germ cell markers (Oct3/4, placental alkaline phosphatase, CD117); it was classified as "delayed germ cell maturation". The remaining 2 specimens (1 patient) were diagnosed as IGCNU but, in retrospect, the patient had an undiagnosed intersex disorder. We therefore did not find a bona fide case of IGCNU in prepubertal testes apart from an intersex disorder.

KW - IGCNU

KW - Intratubular germ cell neoplasia

KW - Prepubertal

KW - Testis

UR - http://www.scopus.com/inward/record.url?scp=84855672269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855672269&partnerID=8YFLogxK

U2 - 10.3109/15513815.2011.618874

DO - 10.3109/15513815.2011.618874

M3 - Article

VL - 31

SP - 21

EP - 24

JO - Fetal and Pediatric Pathology

JF - Fetal and Pediatric Pathology

SN - 1551-3815

IS - 1

ER -