Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?

Lluis Palenzuela, Noah M. Hahn, Robert Nelson, Janet Arno, Carol Schobert, Robert Bethel, Lisa A. Ostrowski, Manjuli R. Sharma, Partha P. Datta, Rajendra K. Agrawal, Jennifer E. Schwartz, Michio Hirano

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.

Original languageEnglish (US)
JournalClinical Infectious Diseases
Volume40
Issue number12
StatePublished - 2005
Externally publishedYes

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Linezolid
Lactic Acidosis
Mitochondrial Proteins
16S Ribosomal RNA
Oxazolidinones
Bacterial Proteins
Genetic Polymorphisms
Protein Binding
Anti-Bacterial Agents

Cite this

Palenzuela, L., Hahn, N. M., Nelson, R., Arno, J., Schobert, C., Bethel, R., ... Hirano, M. (2005). Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis? Clinical Infectious Diseases, 40(12).

Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis? / Palenzuela, Lluis; Hahn, Noah M.; Nelson, Robert; Arno, Janet; Schobert, Carol; Bethel, Robert; Ostrowski, Lisa A.; Sharma, Manjuli R.; Datta, Partha P.; Agrawal, Rajendra K.; Schwartz, Jennifer E.; Hirano, Michio.

In: Clinical Infectious Diseases, Vol. 40, No. 12, 2005.

Research output: Contribution to journalArticle

Palenzuela, L, Hahn, NM, Nelson, R, Arno, J, Schobert, C, Bethel, R, Ostrowski, LA, Sharma, MR, Datta, PP, Agrawal, RK, Schwartz, JE & Hirano, M 2005, 'Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?', Clinical Infectious Diseases, vol. 40, no. 12.
Palenzuela, Lluis ; Hahn, Noah M. ; Nelson, Robert ; Arno, Janet ; Schobert, Carol ; Bethel, Robert ; Ostrowski, Lisa A. ; Sharma, Manjuli R. ; Datta, Partha P. ; Agrawal, Rajendra K. ; Schwartz, Jennifer E. ; Hirano, Michio. / Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?. In: Clinical Infectious Diseases. 2005 ; Vol. 40, No. 12.
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