Does prostate acinar adenocarcinoma with Gleason Score 3+3=6 have the potential to metastasize?

Rodolfo Montironi, Marina Scarpelli, Roberta Mazzucchelli, Antonio Lopez-Beltran, Matteo Santoni, Alberto Briganti, Francesco Montorsi, Liang Cheng

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND: There is a worldwide debate involving clinicians, uropathologists as well as patients and their families on whether Gleason score 6 adenocarcinoma should be labelled as cancer.

CASE DESCRIPTION: We report a case of man diagnosed with biopsy Gleason score 6 acinar adenocarcinoma and classified as low risk (based on a PSA of 5 ng/mL and stage cT2a) whose radical prostatectomy specimen initially showed organ confined Gleason score 3+3=6, WHO nuclear grade 3, acinar adenocarcinoma with lymphovascular invasion and secondary deposit in a periprostatic lymph node. When deeper sections were cut to the point that almost all the slice present in the paraffin block was sectioned, a small tumor area (<5% of the whole tumor) of Gleason pattern 4 (poorly formed glands) was found in an extraprostatic position.

CONCLUSION: The epilogue was that the additional finding changed the final Gleason score to 3+3=6 with tertiary pattern 4 and the stage to pT3a.

VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_190.

Original languageEnglish (US)
Pages (from-to)190
Number of pages1
JournalDiagnostic Pathology
Volume9
DOIs
StatePublished - 2014
Externally publishedYes

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Neoplasm Grading
Prostate
Adenocarcinoma
Neoplasms
Prostatectomy
Paraffin
Lymph Nodes
Biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Does prostate acinar adenocarcinoma with Gleason Score 3+3=6 have the potential to metastasize? / Montironi, Rodolfo; Scarpelli, Marina; Mazzucchelli, Roberta; Lopez-Beltran, Antonio; Santoni, Matteo; Briganti, Alberto; Montorsi, Francesco; Cheng, Liang.

In: Diagnostic Pathology, Vol. 9, 2014, p. 190.

Research output: Contribution to journalArticle

Montironi, R, Scarpelli, M, Mazzucchelli, R, Lopez-Beltran, A, Santoni, M, Briganti, A, Montorsi, F & Cheng, L 2014, 'Does prostate acinar adenocarcinoma with Gleason Score 3+3=6 have the potential to metastasize?', Diagnostic Pathology, vol. 9, pp. 190. https://doi.org/10.1186/s13000-014-0190-z
Montironi, Rodolfo ; Scarpelli, Marina ; Mazzucchelli, Roberta ; Lopez-Beltran, Antonio ; Santoni, Matteo ; Briganti, Alberto ; Montorsi, Francesco ; Cheng, Liang. / Does prostate acinar adenocarcinoma with Gleason Score 3+3=6 have the potential to metastasize?. In: Diagnostic Pathology. 2014 ; Vol. 9. pp. 190.
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AU - Mazzucchelli, Roberta

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AU - Santoni, Matteo

AU - Briganti, Alberto

AU - Montorsi, Francesco

AU - Cheng, Liang

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