Does prostate acinar adenocarcinoma with Gleason Score 3+3=6 have the potential to metastasize?

Rodolfo Montironi, Marina Scarpelli, Roberta Mazzucchelli, Antonio Lopez-Beltran, Matteo Santoni, Alberto Briganti, Francesco Montorsi, Liang Cheng

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

BACKGROUND: There is a worldwide debate involving clinicians, uropathologists as well as patients and their families on whether Gleason score 6 adenocarcinoma should be labelled as cancer.

CASE DESCRIPTION: We report a case of man diagnosed with biopsy Gleason score 6 acinar adenocarcinoma and classified as low risk (based on a PSA of 5 ng/mL and stage cT2a) whose radical prostatectomy specimen initially showed organ confined Gleason score 3+3=6, WHO nuclear grade 3, acinar adenocarcinoma with lymphovascular invasion and secondary deposit in a periprostatic lymph node. When deeper sections were cut to the point that almost all the slice present in the paraffin block was sectioned, a small tumor area (<5% of the whole tumor) of Gleason pattern 4 (poorly formed glands) was found in an extraprostatic position.

CONCLUSION: The epilogue was that the additional finding changed the final Gleason score to 3+3=6 with tertiary pattern 4 and the stage to pT3a.

VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_190.

Original languageEnglish (US)
Article number190
Number of pages1
JournalDiagnostic pathology
Volume9
DOIs
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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    Montironi, R., Scarpelli, M., Mazzucchelli, R., Lopez-Beltran, A., Santoni, M., Briganti, A., Montorsi, F., & Cheng, L. (2014). Does prostate acinar adenocarcinoma with Gleason Score 3+3=6 have the potential to metastasize? Diagnostic pathology, 9, [190]. https://doi.org/10.1186/s13000-014-0190-z