Donor cardiac troponin T: A marker to predict heart transplant rejection

Palaniswamy Vijay, Vincent A. Scavo, Robert J. Morelock, Thomas G. Sharp, John Brown

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background. Noninvasive methodologies have shown poor sensitivity in predicting rejection when compared to serial endomyocardial biopsies. We studied the potential role of donor blood troponin T (Tn-T) as a marker for predicting heart transplant rejection. Methods. Blood cardiac Tn-T was measured from 16 heart donors. Transplant rejection and cardiac function in the recipients were monitored for 1 year. Results. When data were analyzed based on donor blood Tn-T levels, 6 patients who received hearts from donors with low Tn-T (<0.45 ± 0.1 ng/mL) showed no rejection, and patients whose hearts came from donors with higher Tn-T (6.01 ± 0.81 ng/mL) developed episodes of high-grade rejection (3A) within 38.5 ± 2.1 days after transplantation. Eight patients who received hearts from donors with intermediate levels of Tn-T (3.57 ± 0.55 ng/mL) showed mild rejection (grade 1). All recipients had qualitatively normal left ventricular systolic function by serial echocardiography. The mean donor ischemic time was 169 ± 47 minutes. Conclusions. The quality of the donor heart is an important prognostic factor in heart transplantation. It may be possible to identify severely damaged donor organs before transplantation and avoid their use or to develop more aggressive strategies for reducing recurrent acute rejection episodes in high-risk patients.

Original languageEnglish
Pages (from-to)1934-1939
Number of pages6
JournalAnnals of Thoracic Surgery
Volume66
Issue number6
DOIs
StatePublished - 1998

Fingerprint

Troponin T
Graft Rejection
Tissue Donors
Blood Donors
Organ Transplantation
Heart Transplantation
Left Ventricular Function
Echocardiography
Transplantation
Biopsy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Donor cardiac troponin T : A marker to predict heart transplant rejection. / Vijay, Palaniswamy; Scavo, Vincent A.; Morelock, Robert J.; Sharp, Thomas G.; Brown, John.

In: Annals of Thoracic Surgery, Vol. 66, No. 6, 1998, p. 1934-1939.

Research output: Contribution to journalArticle

Vijay, Palaniswamy ; Scavo, Vincent A. ; Morelock, Robert J. ; Sharp, Thomas G. ; Brown, John. / Donor cardiac troponin T : A marker to predict heart transplant rejection. In: Annals of Thoracic Surgery. 1998 ; Vol. 66, No. 6. pp. 1934-1939.
@article{38fb6a29e4d4415eb863fb2bea879d40,
title = "Donor cardiac troponin T: A marker to predict heart transplant rejection",
abstract = "Background. Noninvasive methodologies have shown poor sensitivity in predicting rejection when compared to serial endomyocardial biopsies. We studied the potential role of donor blood troponin T (Tn-T) as a marker for predicting heart transplant rejection. Methods. Blood cardiac Tn-T was measured from 16 heart donors. Transplant rejection and cardiac function in the recipients were monitored for 1 year. Results. When data were analyzed based on donor blood Tn-T levels, 6 patients who received hearts from donors with low Tn-T (<0.45 ± 0.1 ng/mL) showed no rejection, and patients whose hearts came from donors with higher Tn-T (6.01 ± 0.81 ng/mL) developed episodes of high-grade rejection (3A) within 38.5 ± 2.1 days after transplantation. Eight patients who received hearts from donors with intermediate levels of Tn-T (3.57 ± 0.55 ng/mL) showed mild rejection (grade 1). All recipients had qualitatively normal left ventricular systolic function by serial echocardiography. The mean donor ischemic time was 169 ± 47 minutes. Conclusions. The quality of the donor heart is an important prognostic factor in heart transplantation. It may be possible to identify severely damaged donor organs before transplantation and avoid their use or to develop more aggressive strategies for reducing recurrent acute rejection episodes in high-risk patients.",
author = "Palaniswamy Vijay and Scavo, {Vincent A.} and Morelock, {Robert J.} and Sharp, {Thomas G.} and John Brown",
year = "1998",
doi = "10.1016/S0003-4975(98)01057-1",
language = "English",
volume = "66",
pages = "1934--1939",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Donor cardiac troponin T

T2 - A marker to predict heart transplant rejection

AU - Vijay, Palaniswamy

AU - Scavo, Vincent A.

AU - Morelock, Robert J.

AU - Sharp, Thomas G.

AU - Brown, John

PY - 1998

Y1 - 1998

N2 - Background. Noninvasive methodologies have shown poor sensitivity in predicting rejection when compared to serial endomyocardial biopsies. We studied the potential role of donor blood troponin T (Tn-T) as a marker for predicting heart transplant rejection. Methods. Blood cardiac Tn-T was measured from 16 heart donors. Transplant rejection and cardiac function in the recipients were monitored for 1 year. Results. When data were analyzed based on donor blood Tn-T levels, 6 patients who received hearts from donors with low Tn-T (<0.45 ± 0.1 ng/mL) showed no rejection, and patients whose hearts came from donors with higher Tn-T (6.01 ± 0.81 ng/mL) developed episodes of high-grade rejection (3A) within 38.5 ± 2.1 days after transplantation. Eight patients who received hearts from donors with intermediate levels of Tn-T (3.57 ± 0.55 ng/mL) showed mild rejection (grade 1). All recipients had qualitatively normal left ventricular systolic function by serial echocardiography. The mean donor ischemic time was 169 ± 47 minutes. Conclusions. The quality of the donor heart is an important prognostic factor in heart transplantation. It may be possible to identify severely damaged donor organs before transplantation and avoid their use or to develop more aggressive strategies for reducing recurrent acute rejection episodes in high-risk patients.

AB - Background. Noninvasive methodologies have shown poor sensitivity in predicting rejection when compared to serial endomyocardial biopsies. We studied the potential role of donor blood troponin T (Tn-T) as a marker for predicting heart transplant rejection. Methods. Blood cardiac Tn-T was measured from 16 heart donors. Transplant rejection and cardiac function in the recipients were monitored for 1 year. Results. When data were analyzed based on donor blood Tn-T levels, 6 patients who received hearts from donors with low Tn-T (<0.45 ± 0.1 ng/mL) showed no rejection, and patients whose hearts came from donors with higher Tn-T (6.01 ± 0.81 ng/mL) developed episodes of high-grade rejection (3A) within 38.5 ± 2.1 days after transplantation. Eight patients who received hearts from donors with intermediate levels of Tn-T (3.57 ± 0.55 ng/mL) showed mild rejection (grade 1). All recipients had qualitatively normal left ventricular systolic function by serial echocardiography. The mean donor ischemic time was 169 ± 47 minutes. Conclusions. The quality of the donor heart is an important prognostic factor in heart transplantation. It may be possible to identify severely damaged donor organs before transplantation and avoid their use or to develop more aggressive strategies for reducing recurrent acute rejection episodes in high-risk patients.

UR - http://www.scopus.com/inward/record.url?scp=0032467131&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032467131&partnerID=8YFLogxK

U2 - 10.1016/S0003-4975(98)01057-1

DO - 10.1016/S0003-4975(98)01057-1

M3 - Article

C2 - 9930472

AN - SCOPUS:0032467131

VL - 66

SP - 1934

EP - 1939

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 6

ER -