Dopamine D2 receptor availability is associated with subjective responses to alcohol

Karmen Yoder, David Kareken, Regat A. Seyoum, Sean O'Connor, Chunzhi Wang, Qi-Huang Zheng, Bruce Mock, Evan D. Morris

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Background: The mesolimbic dopaminergic system is thought to mediate alcohol abuse and dependence. Determining the relationship between in vivo dopamine and the subjective response to alcohol could improve understanding of the mechanisms that lead to alcohol abuse and dependence. Here, we examined the relationship between dopamine D2 receptors in the nucleus accumbens and scores of perceived "high" and "intoxication" during an intravenous (IV) alcohol infusion. Methods: Nine healthy control subjects received [11C]raclopride PET scanning at baseline. Eight subjects received a second [11C]raclopride scan during a pharmacodynamically modeled and controlled rise of IV alcohol, followed by steady state (60 mg% ± 5 mg%) alcohol infusion. Numerical ratings of "high" and "intoxication" were tested for correlations with measures of dopaminergic function. Results: Baseline D2 receptor availability in the left nucleus accumbens was significantly correlated with peak perceived "intoxication" (p = 0.02) and marginally correlated with peak perceived "high" (p = 0.07). Conclusions: Resting D2 receptor availability may predict healthy subject responses to alcohol exposure.

Original languageEnglish
Pages (from-to)965-970
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume29
Issue number6
DOIs
StatePublished - Jun 2005

Fingerprint

Dopamine D2 Receptors
Alcohols
Alcoholism
Availability
Raclopride
Nucleus Accumbens
Healthy Volunteers
Intravenous Infusions
Positron emission tomography
Dopamine

Keywords

  • Alcohol
  • D Receptor
  • Positron Emission Tomography
  • Raclopride
  • Subjective Perceptions

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Dopamine D2 receptor availability is associated with subjective responses to alcohol. / Yoder, Karmen; Kareken, David; Seyoum, Regat A.; O'Connor, Sean; Wang, Chunzhi; Zheng, Qi-Huang; Mock, Bruce; Morris, Evan D.

In: Alcoholism: Clinical and Experimental Research, Vol. 29, No. 6, 06.2005, p. 965-970.

Research output: Contribution to journalArticle

@article{4e22b501925c40f3b518d216a81e2194,
title = "Dopamine D2 receptor availability is associated with subjective responses to alcohol",
abstract = "Background: The mesolimbic dopaminergic system is thought to mediate alcohol abuse and dependence. Determining the relationship between in vivo dopamine and the subjective response to alcohol could improve understanding of the mechanisms that lead to alcohol abuse and dependence. Here, we examined the relationship between dopamine D2 receptors in the nucleus accumbens and scores of perceived {"}high{"} and {"}intoxication{"} during an intravenous (IV) alcohol infusion. Methods: Nine healthy control subjects received [11C]raclopride PET scanning at baseline. Eight subjects received a second [11C]raclopride scan during a pharmacodynamically modeled and controlled rise of IV alcohol, followed by steady state (60 mg{\%} ± 5 mg{\%}) alcohol infusion. Numerical ratings of {"}high{"} and {"}intoxication{"} were tested for correlations with measures of dopaminergic function. Results: Baseline D2 receptor availability in the left nucleus accumbens was significantly correlated with peak perceived {"}intoxication{"} (p = 0.02) and marginally correlated with peak perceived {"}high{"} (p = 0.07). Conclusions: Resting D2 receptor availability may predict healthy subject responses to alcohol exposure.",
keywords = "Alcohol, D Receptor, Positron Emission Tomography, Raclopride, Subjective Perceptions",
author = "Karmen Yoder and David Kareken and Seyoum, {Regat A.} and Sean O'Connor and Chunzhi Wang and Qi-Huang Zheng and Bruce Mock and Morris, {Evan D.}",
year = "2005",
month = "6",
doi = "10.1097/01.ALC.0000171041.32716.42",
language = "English",
volume = "29",
pages = "965--970",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Dopamine D2 receptor availability is associated with subjective responses to alcohol

AU - Yoder, Karmen

AU - Kareken, David

AU - Seyoum, Regat A.

AU - O'Connor, Sean

AU - Wang, Chunzhi

AU - Zheng, Qi-Huang

AU - Mock, Bruce

AU - Morris, Evan D.

PY - 2005/6

Y1 - 2005/6

N2 - Background: The mesolimbic dopaminergic system is thought to mediate alcohol abuse and dependence. Determining the relationship between in vivo dopamine and the subjective response to alcohol could improve understanding of the mechanisms that lead to alcohol abuse and dependence. Here, we examined the relationship between dopamine D2 receptors in the nucleus accumbens and scores of perceived "high" and "intoxication" during an intravenous (IV) alcohol infusion. Methods: Nine healthy control subjects received [11C]raclopride PET scanning at baseline. Eight subjects received a second [11C]raclopride scan during a pharmacodynamically modeled and controlled rise of IV alcohol, followed by steady state (60 mg% ± 5 mg%) alcohol infusion. Numerical ratings of "high" and "intoxication" were tested for correlations with measures of dopaminergic function. Results: Baseline D2 receptor availability in the left nucleus accumbens was significantly correlated with peak perceived "intoxication" (p = 0.02) and marginally correlated with peak perceived "high" (p = 0.07). Conclusions: Resting D2 receptor availability may predict healthy subject responses to alcohol exposure.

AB - Background: The mesolimbic dopaminergic system is thought to mediate alcohol abuse and dependence. Determining the relationship between in vivo dopamine and the subjective response to alcohol could improve understanding of the mechanisms that lead to alcohol abuse and dependence. Here, we examined the relationship between dopamine D2 receptors in the nucleus accumbens and scores of perceived "high" and "intoxication" during an intravenous (IV) alcohol infusion. Methods: Nine healthy control subjects received [11C]raclopride PET scanning at baseline. Eight subjects received a second [11C]raclopride scan during a pharmacodynamically modeled and controlled rise of IV alcohol, followed by steady state (60 mg% ± 5 mg%) alcohol infusion. Numerical ratings of "high" and "intoxication" were tested for correlations with measures of dopaminergic function. Results: Baseline D2 receptor availability in the left nucleus accumbens was significantly correlated with peak perceived "intoxication" (p = 0.02) and marginally correlated with peak perceived "high" (p = 0.07). Conclusions: Resting D2 receptor availability may predict healthy subject responses to alcohol exposure.

KW - Alcohol

KW - D Receptor

KW - Positron Emission Tomography

KW - Raclopride

KW - Subjective Perceptions

UR - http://www.scopus.com/inward/record.url?scp=21644431608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21644431608&partnerID=8YFLogxK

U2 - 10.1097/01.ALC.0000171041.32716.42

DO - 10.1097/01.ALC.0000171041.32716.42

M3 - Article

C2 - 15976522

AN - SCOPUS:21644431608

VL - 29

SP - 965

EP - 970

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 6

ER -