Dopamine D2 receptors increase in the dorsolateral striatum of weaver mutant mice

Yumiko Kaseda, Bernardino Ghetti, Walter C. Low, Judith A. Richter, Jay R. Simon

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Dopamine D2 receptors were studied in homozygous weaver mutant mice (wv/wv), heterozygous littermates (wv/+), and normal mice (+/+). Specific [3H]spiperone binding was significantly higher in the dorsolateral part of the striatum in the weaver mutant mice (wv/wv) than in normal mice (+/+). No significant differences among the3 genotypes were found in other parts of the striatum or in the nucleus accumbens.

Original languageEnglish
Pages (from-to)178-181
Number of pages4
JournalBrain Research
Volume422
Issue number1
DOIs
StatePublished - Sep 29 1987

Fingerprint

Neurologic Mutant Mice
Dopamine D2 Receptors
Spiperone
Nucleus Accumbens
Genotype

Keywords

  • Dopamine
  • Dopamine D receptor binding assay
  • Nucleus accumbens
  • Striatum
  • Supersensitivity
  • Weaver mutant mouse
  • [H]Spiperone

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Dopamine D2 receptors increase in the dorsolateral striatum of weaver mutant mice. / Kaseda, Yumiko; Ghetti, Bernardino; Low, Walter C.; Richter, Judith A.; Simon, Jay R.

In: Brain Research, Vol. 422, No. 1, 29.09.1987, p. 178-181.

Research output: Contribution to journalArticle

Kaseda, Yumiko ; Ghetti, Bernardino ; Low, Walter C. ; Richter, Judith A. ; Simon, Jay R. / Dopamine D2 receptors increase in the dorsolateral striatum of weaver mutant mice. In: Brain Research. 1987 ; Vol. 422, No. 1. pp. 178-181.
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