Dopamine-depleting effects of MPTP and reserpine in weaver mutant mice

Judith A. Richter, Bernardino Ghetti, Jay R. Simon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The number of nigral dopamine neurons and striatal dopamine levels are reduced by 70% in the adult weaver mutant mouse (wv/wv), whereas these parameters are essentially unchanged in the heterozygote (wv/+). We hypothesized that the remaining nigral dopamine neurons and/or striatal dopamine levels in the weaver would be less sensitive to neurotoxic or dopamine-depleting agents and that nigral neurons in the heterozygote would be more vulnerable. Mice were treated with the dopaminergic neurotoxin MPTP using different injection schedules and also with reserpine. There was a similar percent decrease in striatal DA in weavers and heterozygotes compared to normal mice after these treatments. We did observe a gene-dose-related lethality to the highest dose treatment with MPTP. These results suggest that the remaining dopaminergic neurons in the weaver are not different from those in normal mice in their capacity to respond to MPTP and reserpine.

Original languageEnglish
Pages (from-to)219-228
Number of pages10
JournalMolecular and Chemical Neuropathology
Volume20
Issue number3
DOIs
StatePublished - Dec 1993

Fingerprint

Neurologic Mutant Mice
Corpus Striatum
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Dopamine Agents
Dopaminergic Neurons
Reserpine
Substantia Nigra
Heterozygote
Dopamine
Neurotoxins
Appointments and Schedules
Neurons
Injections
Therapeutics
Genes

Keywords

  • Dopamine
  • lethality
  • MPTP
  • neurotoxicity
  • nigrostriatal
  • reserpine
  • striatum
  • weaver mutant mouse

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Molecular Biology

Cite this

Dopamine-depleting effects of MPTP and reserpine in weaver mutant mice. / Richter, Judith A.; Ghetti, Bernardino; Simon, Jay R.

In: Molecular and Chemical Neuropathology, Vol. 20, No. 3, 12.1993, p. 219-228.

Research output: Contribution to journalArticle

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