Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia

Karmen K. Yoder; Gary D. Hutchins; Evan D. Morris; Allison Brashear; Chunzi Wang; Anantha Shekhar

doi:10.1016/j.schres.2004.03.015

Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia

Karmen K. Yoder, Gary D. Hutchins, Evan D. Morris, Allison Brashear, Chunzi Wang, Anantha Shekhar

Psychiatry

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Striatal dopamine transporter (DAT) binding potential (BP) was compared between schizophrenic subjects with and without tardive dyskinesia and controls. Although the groups were not statistically different in striatal BP, tardive subjects had apparently lower DAT density than non-tardive schizophrenic subjects. Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS.

Original language	English (US)
Pages (from-to)	371-375
Number of pages	5
Journal	Schizophrenia Research
Volume	71
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2004.03.015
State	Published - Dec 1 2004

Keywords

Caudate
Dopamine transporter
PANSS
Putamen
Schizophrenia
Tardive dyskinesia

ASJC Scopus subject areas

Psychiatry and Mental health
Behavioral Neuroscience
Biological Psychiatry
Neurology
Psychology(all)

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AU - Wang, Chunzi

AU - Shekhar, Anantha

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