Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia

Karmen Yoder, Gary Hutchins, Evan D. Morris, Allison Brashear, Chunzi Wang, Anantha Shekhar

Research output: Contribution to journal › Article

33 Citations (Scopus)

Abstract

Striatal dopamine transporter (DAT) binding potential (BP) was compared between schizophrenic subjects with and without tardive dyskinesia and controls. Although the groups were not statistically different in striatal BP, tardive subjects had apparently lower DAT density than non-tardive schizophrenic subjects. Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS.

Original languageEnglish
Pages (from-to)371-375
Number of pages5
JournalSchizophrenia Research
Volume71
Issue number2-3
DOIs
StatePublished - Dec 1 2004

Fingerprint

Dopamine Plasma Membrane Transport Proteins
Corpus Striatum
Anxiety
Depression
Tardive Dyskinesia

Keywords

  • Caudate
  • Dopamine transporter
  • PANSS
  • Putamen
  • Schizophrenia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia. / Yoder, Karmen; Hutchins, Gary; Morris, Evan D.; Brashear, Allison; Wang, Chunzi; Shekhar, Anantha.

In: Schizophrenia Research, Vol. 71, No. 2-3, 01.12.2004, p. 371-375.

Research output: Contribution to journal › Article

Yoder, K, Hutchins, G, Morris, ED, Brashear, A, Wang, C & Shekhar, A 2004, 'Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia', Schizophrenia Research, vol. 71, no. 2-3, pp. 371-375. https://doi.org/10.1016/j.schres.2004.03.015
Yoder K, Hutchins G, Morris ED, Brashear A, Wang C, Shekhar A. Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia. Schizophrenia Research. 2004 Dec 1;71(2-3):371-375. https://doi.org/10.1016/j.schres.2004.03.015
Yoder, Karmen ; Hutchins, Gary ; Morris, Evan D. ; Brashear, Allison ; Wang, Chunzi ; Shekhar, Anantha. / Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia. In: Schizophrenia Research. 2004 ; Vol. 71, No. 2-3. pp. 371-375.
@article{d7bd14ca7c5a426eae1f604e20c06078,
title = "Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia",
abstract = "Striatal dopamine transporter (DAT) binding potential (BP) was compared between schizophrenic subjects with and without tardive dyskinesia and controls. Although the groups were not statistically different in striatal BP, tardive subjects had apparently lower DAT density than non-tardive schizophrenic subjects. Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS.",
keywords = "Caudate, Dopamine transporter, PANSS, Putamen, Schizophrenia, Tardive dyskinesia",
author = "Karmen Yoder and Gary Hutchins and Morris, {Evan D.} and Allison Brashear and Chunzi Wang and Anantha Shekhar",
year = "2004",
month = "12",
day = "1",
doi = "10.1016/j.schres.2004.03.015",
language = "English",
volume = "71",
pages = "371--375",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia

AU - Yoder, Karmen

AU - Hutchins, Gary

AU - Morris, Evan D.

AU - Brashear, Allison

AU - Wang, Chunzi

AU - Shekhar, Anantha

PY - 2004/12/1

Y1 - 2004/12/1

N2 - Striatal dopamine transporter (DAT) binding potential (BP) was compared between schizophrenic subjects with and without tardive dyskinesia and controls. Although the groups were not statistically different in striatal BP, tardive subjects had apparently lower DAT density than non-tardive schizophrenic subjects. Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS.

AB - Striatal dopamine transporter (DAT) binding potential (BP) was compared between schizophrenic subjects with and without tardive dyskinesia and controls. Although the groups were not statistically different in striatal BP, tardive subjects had apparently lower DAT density than non-tardive schizophrenic subjects. Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS.

KW - Caudate

KW - Dopamine transporter

KW - PANSS

KW - Putamen

KW - Schizophrenia

KW - Tardive dyskinesia

UR - http://www.scopus.com/inward/record.url?scp=4944242932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4944242932&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2004.03.015

DO - 10.1016/j.schres.2004.03.015

M3 - Article

C2 - 15474908

AN - SCOPUS:4944242932

VL - 71

SP - 371

EP - 375

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 2-3

ER -

Access to Document